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Bernard M. Babior
Researcher at Scripps Research Institute
Publications - 126
Citations - 20680
Bernard M. Babior is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Oxidase test & NADPH oxidase. The author has an hindex of 58, co-authored 126 publications receiving 20231 citations. Previous affiliations of Bernard M. Babior include Scripps Health & National Institutes of Health.
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Defective superoxide production by granulocytes from patients with chronic granulomatous disease.
TL;DR: Superoxide-dependent cytochrome c reduction was used to measure Superoxide production by granulocytes from two patients with chronic granulomatous disease and from children of similar age with similar age who had similar age-like symptoms.
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Neutrophils and Host Defense
TL;DR: Neutrophils, the predominant phagocytes of circulating blood, are the first cells to arrive at sites of infection and are recognized to predispose to infection.
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Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation.
Paul Wentworth,Jonathan E. McDunn,Anita D. Wentworth,Cindy Takeuchi,Jorge Nieva,Teresa M. Jones,Cristina Bautista,Julie M. Ruedi,Abel Gutierrez,Kim D. Janda,Bernard M. Babior,Albert Eschenmoser,Richard A. Lerner +12 more
TL;DR: It is shown that antibodies catalyze the generation of hydrogen peroxide from singlet molecular oxygen and water, and this process can lead to efficient killing of bacteria, regardless of the antigen specificity of the antibody.
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The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.
TL;DR: Using immunopurified p47phox isolated from 32Pi-loaded neutrophils activated with phorbol myristate acetate, it is shown that all the 32P was in the C-terminal CNBr fragment of the protein, and that the same serines were phosphorylated in response to each agent.
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Oxidant-induced Vascular Endothelial Growth Factor Expression in Human Keratinocytes and Cutaneous Wound Healing
Chandan K. Sen,Savita Khanna,Bernard M. Babior,Thomas K. Hunt,E. Christopher Ellison,Sashwati Roy +5 more
TL;DR: In this paper, the effect of NADPH oxidase-generated reactive oxygen species on wound healing in vivo, Rac1 gene transfer was performed to dermal excisional wounds left to heal by secondary intention.