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Bernardo Orr
Researcher at Instituto de Biologia Molecular e Celular
Publications - 22
Citations - 599
Bernardo Orr is an academic researcher from Instituto de Biologia Molecular e Celular. The author has contributed to research in topics: Mitosis & Anaphase. The author has an hindex of 11, co-authored 19 publications receiving 461 citations. Previous affiliations of Bernardo Orr include University of Porto & Dartmouth–Hitchcock Medical Center.
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Journal ArticleDOI
Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator
Mariana Lince-Faria,Stefano Maffini,Bernardo Orr,Yun Ding,Cláudia Florindo,Claudio E. Sunkel,Álvaro A. Tavares,Jørgen Johansen,Kristen M. Johansen,Helder Maiato +9 more
TL;DR: It is proposed that Mtor/Tpr functions as a spatial regulator of the SAC, which ensures the efficient recruitment ofMad2 to unattached KTs at the onset of mitosis and proper spindle maturation, whereas enrichment of Mad2 in a spindle matrix helps confine the action of a diffusible “wait anaphase” signal to the vicinity of the spindle.
Journal ArticleDOI
A Double-Edged Sword: How Oncogenes and Tumor Suppressor Genes Can Contribute to Chromosomal Instability
Bernardo Orr,Duane A. Compton +1 more
TL;DR: The results indicate that the induction of CIN can no longer be considered separately from the cancer-associated driver mutations and how the oncogenic activation of key signal transduction pathways contributes to the inductionof CIN is discussed.
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Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells
TL;DR: A small molecule (UMK57) is explored using a small molecule that suppresses chromosome mis-segregation in CIN cancer cells by potentiating the activity of the kinesin-13 protein MCAK and shows adaptive resistance to therapies targeting CIN through rapid and reversible changes to mitotic signaling networks.
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Mad2-independent spindle assembly checkpoint activation and controlled metaphase-anaphase transition in Drosophila s2 cells
TL;DR: Results strongly suggest that Mad2 is exclusively required to delay progression through early stages of prometaphase so that cells have time to fully engage the spindle assembly checkpoint, allowing a controlled metaphase-anaphase transition and normal patterns of chromosome segregation.
Journal ArticleDOI
Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2.
Jung-Sik Kim,Xiaoyuan He,Bernardo Orr,Gordana Wutz,Victoria K. Hill,Jan-Michael Peters,Duane A. Compton,Todd Waldman +7 more
TL;DR: The data indicate that not all tumor-derived STAG2 mutations confer defects in cohesion, chromosome segregation, and ploidy, suggesting that there are likely to be other functional effects of STAG1 inactivation in human cancer cells that are relevant to cancer pathogenesis.