Beverley B. Matthews

TL;DR: These major new features and functionalities of the FlyBase 2.0 site are described and how they support the use of Drosophila as a model organism for biological discovery and translational research are described.

TL;DR: New features, datasets, reagent collections, and data presentations are described that address the needs of the Drosophila research community, including enhanced orthology data, Human Disease Model Reports, protein domain search and visualization, concise gene summaries, and a portal for external resources.

TL;DR: FlyBase biologists successfully used Apollo to annotate the Drosophila melanogaster genome and it is increasingly being used as a starting point for the development of customized annotation editing tools for other genome projects.

TL;DR: Identification of so many unusual gene models in Drosophila suggests that some mechanisms for gene regulation are more prevalent than previously believed, and underscores the complex challenges of eukaryotic gene prediction.

TL;DR: Direct genome-wide searches for unusual protein-coding structures are performed, discovering 149 possible examples of stop codon readthrough, 125 new candidate ORFs of polycistronic mRNAs, and several candidate translational frameshifts.