S
Sima Misra
Researcher at University of California, Berkeley
Publications - 16
Citations - 5074
Sima Misra is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 13, co-authored 16 publications receiving 4859 citations. Previous affiliations of Sima Misra include Lawrence Berkeley National Laboratory.
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Journal ArticleDOI
Comparative Genomics of the Eukaryotes
Gerald M. Rubin,Mark Yandell,Jennifer R. Wortman,George L. Gabor,Miklos,Catherine R. Nelson,Iswar K. Hariharan,Mark E. Fortini,Peter W. Li,Rolf Apweiler,Wolfgang Fleischmann,J. Michael Cherry,Steven Henikoff,Marian P. Skupski,Sima Misra,Michael Ashburner,Ewan Birney,Mark S. Boguski,Thomas Brody,Peter Brokstein,Susan E. Celniker,Stephen A. Chervitz,David Coates,Anibal Cravchik,Andrei Gabrielian,Richard F. Galle,William M. Gelbart,Reed A. George,Lawrence S.B. Goldstein,Fangcheng Gong,Ping Guan,Nomi L. Harris,Bruce A. Hay,Roger A. Hoskins,Jiayin Li,Zhenya Li,Richard O. Hynes,Steven J.M. Jones,Peter M. Kuehl,Bruno Lemaitre,J. Troy Littleton,Deborah K. Morrison,Christopher J. Mungall,Patrick H. O'Farrell,Oxana K. Pickeral,Chris Shue,Leslie B. Vosshall,Jiong Zhang,Qi Zhao,Xiangqun H. Zheng,Fei Zhong,Wenyan Zhong,Richard A. Gibbs,J. Craig Venter,Mark Raymond Adams,Suzanna E. Lewis +55 more
TL;DR: The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.
Journal ArticleDOI
Tools for neuroanatomy and neurogenetics in Drosophila
Barret D. Pfeiffer,Arnim Jenett,Ann S. Hammonds,Teri T.B. Ngo,Sima Misra,Christine Murphy,Audra Scully,Joseph W. Carlson,Kenneth H. Wan,Todd R. Laverty,Christopher J. Mungall,Rob Svirskas,James T. Kadonaga,Chris Q. Doe,Michael B. Eisen,Susan E. Celniker,Gerald M. Rubin +16 more
TL;DR: The results suggest that the D. melanogaster genome contains >50,000 enhancers and that multiple enhancers drive distinct subsets of expression of a gene in each tissue and developmental stage.
Journal ArticleDOI
The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes.
Allan C. Spradling,David B. Stern,Amy Beaton,E J Rhem,Todd R. Laverty,N Mozden,Sima Misra,Gerald M. Rubin +7 more
TL;DR: The results show that Drosophila genes have a wide range of sensitivity to inactivation by P elements, and provide a rationale for greatly expanding the BDGP primary collection based entirely on insertion site sequencing, and predict that this approach can bring >85% of all Dosophila open reading frames under experimental control.
Journal ArticleDOI
Apollo: a sequence annotation editor
Suzanna E. Lewis,Smj Searle,Nomi L. Harris,Nomi L. Harris,M Gibson,Vivek Iyer,J. Richter,Colin Wiel,Leyla Bayraktaroglu,Ewan Birney,Madeline A. Crosby,Joshua S. Kaminker,Beverley B. Matthews,Simon Prochnik,Christopher D. Smith,Jonathan L. Tupy,Gerald M. Rubin,Sima Misra,Christopher J. Mungall,Michele Clamp +19 more
TL;DR: FlyBase biologists successfully used Apollo to annotate the Drosophila melanogaster genome and it is increasingly being used as a starting point for the development of customized annotation editing tools for other genome projects.
Journal ArticleDOI
Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.
Sima Misra,Madeline A. Crosby,Christopher J. Mungall,Beverley B. Matthews,Kathryn S. Campbell,Pavel Hradecky,Yanmei Huang,Joshua S. Kaminker,Gillian Millburn,Simon Prochnik,Christopher D. Smith,Jonathan L. Tupy,Eleanor J Whitfield,Leyla Bayraktaroglu,Benjamin P. Berman,Bettencourt Brian,Susan E. Celniker,Aubrey D.N.J. de Grey,Rachel Drysdale,Nomi L. Harris,Nomi L. Harris,J. Richter,Susan M. Russo,Andrew J. Schroeder,ShengQiang Shu,Mark Stapleton,Chihiro Yamada,Michael Ashburner,William M. Gelbart,Gerald M. Rubin,Suzanna E. Lewis +30 more
TL;DR: Identification of so many unusual gene models in Drosophila suggests that some mechanisms for gene regulation are more prevalent than previously believed, and underscores the complex challenges of eukaryotic gene prediction.