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Bhagya C. Thimmappa
Researcher at Jawaharlal Nehru Centre for Advanced Scientific Research
Publications - 15
Citations - 248
Bhagya C. Thimmappa is an academic researcher from Jawaharlal Nehru Centre for Advanced Scientific Research. The author has contributed to research in topics: Centromere & DNA sequencing. The author has an hindex of 7, co-authored 14 publications receiving 180 citations.
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Journal ArticleDOI
RNAi is a critical determinant of centromere evolution in closely related fungi.
Vikas Yadav,Sheng Sun,R. Blake Billmyre,Bhagya C. Thimmappa,Terrance Shea,Robert E. Lintner,Guus Bakkeren,Christina A. Cuomo,Joseph Heitman,Kaustuv Sanyal +9 more
TL;DR: Evidence is presented suggesting that the loss of RNAi and cytosine DNA methylation triggered transposon attrition, which resulted in shortening of centromere length during evolution.
Journal ArticleDOI
Loss of centromere function drives karyotype evolution in closely related Malassezia species
Sundar Ram Sankaranarayanan,Giuseppe Ianiri,Marco A. Coelho,Md. Hashim Reza,Bhagya C. Thimmappa,Promit Ganguly,Rakesh Netha Vadnala,Sheng Sun,Rahul Siddharthan,Christian Tellgren-Roth,Thomas L. Dawson,Thomas L. Dawson,Joseph Heitman,Kaustuv Sanyal +13 more
TL;DR: It is proposed that AT-rich centromeres drive karyotype diversity in the Malassezia species complex through breakage and inactivation, which suggests two distinct mechanisms of chromosome number reduction from an inferred nine-chromosome ancestral state.
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Long transposon-rich centromeres in an oomycete reveal divergence of centromere features in Stramenopila-Alveolata-Rhizaria lineages.
Yufeng Fang,Marco A. Coelho,Haidong Shu,Klaas Schotanus,Bhagya C. Thimmappa,Vikas Yadav,Han Chen,Ewa P. Malc,Jeremy Wang,Piotr A. Mieczkowski,Brent A. Kronmiller,Brett M. Tyler,Kaustuv Sanyal,Suomeng Dong,Minou Nowrousian,Joseph Heitman +15 more
TL;DR: A divergence of centromere features in oomycetes as compared to other organisms in the Stramenopila-Alveolata-Rhizaria (SAR) supergroup including diatoms and Plasmodium falciparum that have relatively short and simple regional centromeres is revealed.
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Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres.
Krishnendu Guin,Yao Chen,Radha Mishra,Siti Rawaidah B.M. Muzaki,Bhagya C. Thimmappa,Caoimhe E. O’Brien,Geraldine Butler,Amartya Sanyal,Kaustuv Sanyal +8 more
TL;DR: It is proposed that spatial proximity of the homologous centromere DNA sequences facilitated karyotype rearrangements and centreromere type transitions in human pathogenic yeasts of the CUG-Ser1 clade.
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Cis- and Trans-chromosomal Interactions Define Pericentric Boundaries in the Absence of Conventional Heterochromatin
TL;DR: This study identifies a specialized CEN-proximal domain that specifies and restricts the centromeric activity to a unique region and shows that neocentromere activation on chromosome 7 occurs within this specified region.