Loss of centromere function drives karyotype evolution in closely related Malassezia species
Sundar Ram Sankaranarayanan,Giuseppe Ianiri,Marco A. Coelho,Md. Hashim Reza,Bhagya C. Thimmappa,Promit Ganguly,Rakesh Netha Vadnala,Sheng Sun,Rahul Siddharthan,Christian Tellgren-Roth,Thomas L. Dawson,Thomas L. Dawson,Joseph Heitman,Kaustuv Sanyal +13 more
TLDR
It is proposed that AT-rich centromeres drive karyotype diversity in the Malassezia species complex through breakage and inactivation, which suggests two distinct mechanisms of chromosome number reduction from an inferred nine-chromosome ancestral state.Abstract:
Genomic rearrangements associated with speciation often result in variation in chromosome number among closely related species. Malassezia species show variable karyotypes ranging between six and nine chromosomes. Here, we experimentally identified all eight centromeres in M. sympodialis as 3-5-kb long kinetochore-bound regions that span an AT-rich core and are depleted of the canonical histone H3. Centromeres of similar sequence features were identified as CENP-A-rich regions in Malassezia furfur, which has seven chromosomes, and histone H3 depleted regions in Malassezia slooffiae and Malassezia globosa with nine chromosomes each. Analysis of synteny conservation across centromeres with newly generated chromosome-level genome assemblies suggests two distinct mechanisms of chromosome number reduction from an inferred nine-chromosome ancestral state: (a) chromosome breakage followed by loss of centromere DNA and (b) centromere inactivation accompanied by changes in DNA sequence following chromosome-chromosome fusion. We propose that AT-rich centromeres drive karyotype diversity in the Malassezia species complex through breakage and inactivation.read more
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Cutaneous Malassezia: Commensal, Pathogen, or Protector?
Shree Harsha Vijaya Chandra,Ramasamy Srinivas,Thomas L. Dawson,Thomas L. Dawson,John E.A. Common +4 more
TL;DR: A recent review as mentioned in this paper discusses recent developments that have expanded our understanding of Malassezia's role in the skin microbiome, with a focus on its multiple roles in health and disease as commensal, pathogen, and protector.
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A unique chromatin profile defines adaptive genomic regions in a fungal plant pathogen.
David Cook,H. Martin Kramer,David E Torres,David E Torres,Michael F. Seidl,Michael F. Seidl,Bart P. H. J. Thomma,Bart P. H. J. Thomma +7 more
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Advances in understanding the evolution of fungal genome architecture
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The evolving species concepts used for yeasts: from phenotypes and genomes to speciation networks.
Teun Boekhout,Teun Boekhout,M. Catherine Aime,Dominik Begerow,Toni Gabaldón,Joseph Heitman,Martin Kemler,Kantarawee Khayhan,Marc-André Lachance,Edward J. Louis,Sheng Sun,Duong Vu,Andrey Yurkov +12 more
TL;DR: P phylogenetic species concepts that employ sequence data of rDNA and other genes are universally applied in fungal taxonomy, including yeasts, because various studies revealed a relatively good correlation between the biological species concept and sequence divergence.
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Repetitive elements contribute to the diversity and evolution of centromeres in the fungal genus verticillium
Michael F. Seidl,Michael F. Seidl,H. Martin Kramer,David Cook,David Cook,Gabriel L. Fiorin,Grardy C. M. van den Berg,Luigi Faino,Luigi Faino,Bart P. H. J. Thomma,Bart P. H. J. Thomma +10 more
TL;DR: The contribution of repetitive elements to the diversity and rapid evolution of centromeres within the fungal genus Verticillium is highlighted, and centromere size was found to correlate with the genome-wide repeat content.
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