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Bin Sheng Wong
Researcher at Johns Hopkins University
Publications - 15
Citations - 930
Bin Sheng Wong is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Metastasis & Cell migration. The author has an hindex of 9, co-authored 15 publications receiving 741 citations. Previous affiliations of Bin Sheng Wong include National University of Singapore.
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Journal ArticleDOI
Carbon nanotubes for delivery of small molecule drugs
Bin Sheng Wong,Sia Lee Yoong,Anna Jagusiak,Tomasz Panczyk,Han Kiat Ho,Wee Han Ang,Giorgia Pastorin +6 more
TL;DR: The delivery of small molecule drugs is expounded, with special attention paid to the current progress of in vitro and in vivo research involving CNT-based DDSs, before finally concluding with some consideration on inevitable complications that hamper successful disease intervention with CNTs.
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Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways
Wei Chien Hung,Jessica Yang,Christopher L. Yankaskas,Bin Sheng Wong,Pei Hsun Wu,Carlos Pardo-Pastor,Selma A. Serra,Meng Jung Chiang,Zhizhan Gu,Denis Wirtz,Denis Wirtz,Miguel A. Valverde,Joy T. Yang,Jin Zhang,Konstantinos Konstantopoulos,Konstantinos Konstantopoulos +15 more
TL;DR: This study provides a mechanism by which confinement-induced signaling enables cells to sense and adapt to different physical microenvironments and indicates that these proteins can independently mediate confinement sensing.
Journal ArticleDOI
Enhanced cytotoxicity to cancer cells by mitochondria-targeting MWCNTs containing platinum(IV) prodrug of cisplatin.
Sia Lee Yoong,Bin Sheng Wong,Qiling Zhou,Chee Fei Chin,Jian Li,Thirumalai Venkatesan,Han Kiat Ho,Victor C. Yu,Victor C. Yu,Wee Han Ang,Giorgia Pastorin,Giorgia Pastorin +11 more
TL;DR: Due to its targeting capability and apparent lack of cytotoxicity, MWCNT-Rho complex was used to co-encapsulate PtBz and a chemo-potentiator, 3-bromopyruvate (BP), and the resulting MWCNRho(PtBz+BP) construct demonstrated superior efficacy over PtBZ free drug in several cancer cell lines tested.
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Polycaprolactone scaffold as targeted drug delivery system and cell attachment scaffold for postsurgical care of limb salvage
TL;DR: A dual-function drug-laden polycaprolactone scaffold, which can serve as both targeted drug delivery system and attachment platform for tissue regeneration for the postsurgical care of limb salvage procedure, was developed with a simple and solvent-free molding technique.
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A Direct Podocalyxin-Dynamin-2 Interaction Regulates Cytoskeletal Dynamics to Promote Migration and Metastasis in Pancreatic Cancer Cells
Bin Sheng Wong,Daniel J. Shea,Panagiotis Mistriotis,Soontorn Tuntithavornwat,Robert A. Law,Jake M. Bieber,Lei Zheng,Konstantinos Konstantopoulos +7 more
TL;DR: It is revealed that a novel interaction between podocalyxin and dynamin-2 promotes migration and metastasis of pancreatic cancer cells by regulating microtubule and focal adhesion dynamics.