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Pei Hsun Wu
Researcher at Johns Hopkins University
Publications - 76
Citations - 3579
Pei Hsun Wu is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 25, co-authored 58 publications receiving 2552 citations. Previous affiliations of Pei Hsun Wu include Johns Hopkins University School of Medicine & University of Florida.
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Journal ArticleDOI
A comparison of methods to assess cell mechanical properties.
Pei Hsun Wu,Dikla Raz-Ben Aroush,Atef Asnacios,Wei Chiang Chen,Maxim Dokukin,Bryant L. Doss,Pauline Durand-Smet,Andrew Ekpenyong,Jochen Guck,Nataliia Guz,Paul A. Janmey,Jerry S.H. Lee,Jerry S.H. Lee,Nicole M. Moore,Albrecht Ott,Yeh Chuin Poh,Robert Ros,Mathias Sander,Igor M. Sokolov,Jack R. Staunton,Ning Wang,Graeme Whyte,Denis Wirtz +22 more
TL;DR: This Analysis compares and contrasts methods for measuring the mechanical properties of cells by applying the different approaches to the same breast cancer cell line, highlighting how elastic and viscous moduli of MCF-7 breast cancer cells can vary 1,000-fold and 100-fold.
Journal ArticleDOI
Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes
Amit Agarwal,Pei Hsun Wu,Ethan G. Hughes,Masahiro Fukaya,Max A. Tischfield,Abraham J. Langseth,Denis Wirtz,Dwight E. Bergles +7 more
TL;DR: By localizing mitochondria to microdomains, astrocytes ensure local metabolic support for energetically demanding processes and enable coupling between metabolic demand and Ca2+ signaling events.
Journal ArticleDOI
Three-dimensional cell migration does not follow a random walk
TL;DR: This paper introduces and validate a new model of 3D cell migration that takes into account cell heterogeneity and the anisotropic movements induced by local remodeling of the 3D matrix, and reveals the unexpected robust relation between cell speed and persistence of migration over a wide range of matrix densities.
Journal ArticleDOI
Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions.
Stephanie I. Fraley,Pei Hsun Wu,Lijuan He,Yunfeng Feng,Ranjini Krisnamurthy,Gregory D. Longmore,Gregory D. Longmore,Denis Wirtz +7 more
TL;DR: The results suggest that fiber topography guides protrusions and thereby MMP activity and motility, and a threshold of MMP utility was identified.
Journal ArticleDOI
A physical sciences network characterization of non-tumorigenic and metastatic cells
David B. Agus,Jenolyn F. Alexander,Wadih Arap,S.P. Ashili,Joseph E. Aslan,Robert H. Austin,Vadim Backman,Kelly Bethel,Richard Bonneau,Wei Chiang Chen,Chira Chen-Tanyolac,Nathan C. Choi,Steven A. Curley,Matthew R. Dallas,Dhwanil Damania,Paul Davies,Paolo Decuzzi,Laura E. Dickinson,Luis Estévez-Salmerón,Veronica Estrella,Mauro Ferrari,Claudia Fischbach,Jasmine Foo,Stephanie I. Fraley,Christian Frantz,Alexander Fuhrmann,Philippe Gascard,Robert A. Gatenby,Yue Geng,Sharon Gerecht,Robert J. Gillies,Biana Godin,William M. Grady,William M. Grady,Alex Greenfield,Courtney Hemphill,Barbara L. Hempstead,Abigail Hielscher,W. Daniel Hillis,Eric C. Holland,Arig Ibrahim-Hashim,Tyler Jacks,Roger H. Johnson,Ahyoung Joo,Jonathan E. Katz,Laimonas Kelbauskas,Carl Kesselman,Michael R. King,Konstantinos Konstantopoulos,Casey M. Kraning-Rush,Peter Kuhn,Kevin S. Kung,Brian J. Kwee,Johnathon N. Lakins,Guillaume Lambert,David Liao,Jonathan D. Licht,Jan Liphardt,Jan Liphardt,Liyu Liu,Mark C. Lloyd,Anna Lyubimova,Parag Mallick,Parag Mallick,John F. Marko,Owen J. T. McCarty,Deirdre R. Meldrum,Franziska Michor,Shannon M. Mumenthaler,Vivek Nandakumar,Thomas V. O'Halloran,Steve Oh,Renata Pasqualini,Matthew J. Paszek,Kevin G. Philips,Christopher S. Poultney,Kuldeepsinh Rana,Cynthia A. Reinhart-King,Robert Ros,Gregg L. Semenza,Patti Senechal,Michael L. Shuler,Srimeenakshi Srinivasan,Jack R. Staunton,Yolanda Stypula,Hariharan Subramanian,Thea D. Tlsty,Garth W. Tormoen,Yiider Tseng,Yiider Tseng,Alexander van Oudenaarden,Scott S. Verbridge,Scott S. Verbridge,Jenny C. Wan,Valerie M. Weaver,Jonathan Widom,Christine Will,Denis Wirtz,Jonathan W. Wojtkowiak,Pei Hsun Wu +99 more
TL;DR: Comparisons of the non-tumorigenic MCF-10A and metastatic MDA-MB-231 breast epithelial cell lines, commonly used as models of cancer metastasis, reveal dramatic differences in their mechanics, migration, adhesion, oxygen response, and proteomic profiles.