Soontorn Tuntithavornwat

TL;DR: A conceptual model in which confinement-induced RhoA/myosin-II activation promotes nuclear volume expansion, nuclear envelope blebbing, and rupture by triggering passive nuclear influx from the cell posterior, ultimately leading to reduced cell motility is proposed.

TL;DR: In this article, a molecular mechanism by which cells avoid high fluid shear during intravasation was described using a microfluidic device where cells migrating inside longitudinal tissue-like microchannels encounter an orthogonal channel in which fluid flow induces physiological shear stresses.

TL;DR: It is demonstrated that dorsoventral polarity, observed in vivo and in vitro, directs cell responses in confinement by spatially tuning RhoA activity, which controls bleb-based versus mesenchymal migration.

TL;DR: It is revealed that a novel interaction between podocalyxin and dynamin-2 promotes migration and metastasis of pancreatic cancer cells by regulating microtubule and focal adhesion dynamics.

TL;DR: The role of giant obscurins in pancreatic cancer progression and metastasis has been delineated in this paper, which reveals a critical role of OBSCN as tumor suppressors in normal pancreatic epithelium.