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Bingbing Jiang
Researcher at Boston University
Publications - 13
Citations - 2740
Bingbing Jiang is an academic researcher from Boston University. The author has contributed to research in topics: AMP-activated protein kinase & Nitric oxide synthase. The author has an hindex of 12, co-authored 12 publications receiving 2389 citations. Previous affiliations of Bingbing Jiang include Brigham and Women's Hospital.
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Journal ArticleDOI
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice.
Yu Li,Shanqin Xu,Maria M. Mihaylova,Bin Zheng,Xiuyun Hou,Bingbing Jiang,Ogyi Park,Zhijun Luo,Etienne Lefai,John Y.-J. Shyy,Bin Gao,Michel Wierzbicki,Tony Verbeuren,Reuben J. Shaw,Richard A. Cohen,Mengwei Zang +15 more
TL;DR: It is demonstrated that AMPK interacts with and directly phosphorylates sterol regulatory element binding proteins (SREBP-1c and -2) and AMPK-dependent phosphorylation of SREBP may offer therapeutic strategies to combat insulin resistance, dyslipidemia, and atherosclerosis.
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SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase *
Xiuyun Hou,Shanqin Xu,Karlene A. Maitland-Toolan,Kaori Sato,Bingbing Jiang,Yasuo Ido,Fan Lan,Kenneth Walsh,Michel Wierzbicki,Tony Verbeuren,Richard A. Cohen,Mengwei Zang +11 more
TL;DR: It is shown that polyphenols, including resveratrol and the synthetic polyphenol S17834, increase SIRT1 deacetylase activity, LKB1 phosphorylation at Ser428, and AMPK activity, which suggests that Sirt1 functions as a novel upstream regulator for L KB1/AMPK signaling and plays an essential role in the regulation of hepatocyte lipid metabolism.
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Temporal Control of NF-κB Activation by ERK Differentially Regulates Interleukin-1β-induced Gene Expression
TL;DR: Although NF-κB activation was essential for interleukin-1β induction of each of the proteins studied, gene expression was differentially regulated by ERK and by the duration of NF-kkB activation.
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AMPK Activation by Metformin Suppresses Abnormal Extracellular Matrix Remodeling in Adipose Tissue and Ameliorates Insulin Resistance in Obesity.
Ting Luo,Allison Nocon,Jessica L. Fry,Alex Sherban,Xianliang Rui,Bingbing Jiang,X. Julia Xu,Jingyan Han,Yun Yan,Qin Yang,Qifu Li,Mengwei Zang +11 more
TL;DR: Treatment with the antidiabetic drug metformin inhibits excessive ECM deposition in WAT of ob/ob mice and mice with diet-induced obesity, as evidenced by decreased collagen deposition surrounding adipocytes and expression of fibrotic genes including the collagen cross-linking regulator LOX.
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Persistent Activation of Nuclear Factor-κB by Interleukin-1β and Subsequent Inducible NO Synthase Expression Requires Extracellular Signal-Regulated Kinase
TL;DR: Data suggest that ERK activity is required for persistent NF-&kgr;B activation by IL-1&bgr; that is necessary for iNOS gene expression.