Binxia Chang

TL;DR: An HFD combined with acute ethanol consumption synergistically induces acute liver inflammation and injury through the elevation of hepatic or serum free fatty acids and subsequent up‐regulation of hepatics CXCL1 expression and promotion of liver neutrophil infiltration.

TL;DR: Chronic-plus-binge ethanol feeding of mice, which mimics the drinking pattern of patients with AH, produced severe ASH and mild fibrosis and microarray analyses revealed similar alterations in expression of many hepatic genes in ethanol-fed mice and humans with ASH, including up-regulation of mouse Fsp27 (also called Cidec) and human CIDEC.

TL;DR: Recently identified therapeutic targets that inhibit inflammation, ameliorate hepatocyte death, and promote liver repair in ALD are discussed, with a focus on the recent studies on the immunosuppressive drug prednisolone and the hepatoprotective cytokine interleukin-22.

TL;DR: In this article , no consensus regarding the indications for corticosteroids for chronic DILI/HILI was established. But, there is no consensus on the use of corticostosteroids in the treatment of HILI or drug-induced liver injury.

TL;DR: Wang et al. as discussed by the authors developed a nomogram model to predict transplant-free survival (TFS) in patients with non-acetaminophen (APAP) drug-induced acute liver failure (ALF).