Birgit Ledermann

TL;DR: To study the pathogenesis of the neurologic symptoms of AIP, Pbgd-deficient mice are generated by gene targeting and reveal decreased motor function and-histo-pathological findings include axonal neuropathy and neurologic muscle atrophy.

TL;DR: It is concluded that IgD is largely able to substitute for IgM functions in mice deficient in B cells, and survived infection with vesicular stomatitis virus by developing neutralizing immunoglobulins, but they were more susceptible than wild-type controls with delayed specific Immunoglobulin responses.

TL;DR: This newly-characterized BALB/c-ES cell line thus provides an alternative to the traditional 129-derived and the recently described C57BL/6 embryonic stem cell lines, and will be useful in disrupting genes involved in the immune system.

TL;DR: This work studied the effect of wnt signalling in embryonic stem cells by either inactivating APC or by introducing a dominant active form of beta-catenin, finding that neural differentiation could be partially restored by the addition of the BMP antagonist noggin.

TL;DR: Data indicate that perforin is not essential in the cell‐mediated acute rejection of a fully mismatched heart allograft, and Perforin‐dependent effector mechanisms appeared to be limiting in the T cellmediated rejection of heart allogsrafts differing only at a single major histocompatibility complex class I antigen.