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Bjarni Thjodleifsson
Researcher at University of Iceland
Publications - 43
Citations - 2980
Bjarni Thjodleifsson is an academic researcher from University of Iceland. The author has contributed to research in topics: Population & Naproxen. The author has an hindex of 22, co-authored 43 publications receiving 2765 citations.
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Journal ArticleDOI
Large-scale whole-genome sequencing of the Icelandic population
Daniel F. Gudbjartsson,Hannes Helgason,Sigurjon A. Gudjonsson,Florian Zink,Asmundur Oddson,Arnaldur Gylfason,Søren Besenbacher,Gisli Magnusson,Bjarni V. Halldorsson,Eirikur Hjartarson,Gunnar Th. Sigurdsson,Simon N. Stacey,Michael L. Frigge,Hilma Holm,Jona Saemundsdottir,Hafdis T. Helgadottir,Hrefna Johannsdottir,Gunnlaugur Sigfússon,Gudmundur Thorgeirsson,Jon Th. Sverrisson,Solveig Gretarsdottir,G. Bragi Walters,Thorunn Rafnar,Bjarni Thjodleifsson,Einar Björnsson,Sigurdur Olafsson,Hildur Thorarinsdottir,Thora Steingrimsdottir,Thora S. Gudmundsdottir,Ásgeir Theodórs,Jon G. Jonasson,Asgeir Sigurdsson,Gyda Bjornsdottir,Jon J. Jonsson,Ólafur Thorarensen,Petur Ludvigsson,Hakon Gudbjartsson,Gudmundur I. Eyjolfsson,Olof Sigurdardottir,Isleifur Olafsson,David O. Arnar,Olafur Th Magnusson,Augustine Kong,Gisli Masson,Unnur Thorsteinsdottir,Agnar Helgason,Patrick Sulem,Kari Stefansson +47 more
TL;DR: The insights gained from sequencing the whole genomes of Icelanders to a median depth of 20× provide a study design that can be used to determine how variation in the sequence of the human genome gives rise to human diversity.
Journal ArticleDOI
A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy.
TL;DR: This study provides both biochemical and direct evidence of macroscopic injury to the small intestine in 68%-75% of volunteers resulting from 2 weeks' ingestion of slow-release diclofenac.
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Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease.
Ken Takeuchi,Simon Smale,Purushothaman Premchand,Laurence Maiden,Roy Sherwood,Bjarni Thjodleifsson,Einar Björnsson,Ingvar Bjarnason +7 more
TL;DR: NSAID ingestion is associated with frequent and early clinical relapse of quiescent inflammatory bowel disease, and the mechanism appears to be due to dual inhibition of the COX enzymes.
Journal ArticleDOI
Long-term effects of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective agents on the small bowel: a cross-sectional capsule enteroscopy study.
Laurence Maiden,Bjarni Thjodleifsson,Anna Seigal,Ingvar Bjarnason,David Scott,Sigurbjorn Birgisson,Ingvar Bjarnason +6 more
TL;DR: An important role for COX-2 in the maintenance of small-bowel integrity is suggested, which has implications for strategies that aim to minimize the gastrointestinal damage in patients requiring anti-inflammatory analgesics.
Journal ArticleDOI
C reactive protein levels are increased in non-allergic but not allergic asthma: a multicentre epidemiological study
Inga Sif Ólafsdóttir,T. Gislason,Bjarni Thjodleifsson,Isleifur Olafsson,Davíð Gíslason,Rain Jõgi,C Janson +6 more
TL;DR: Raised levels of HsCRP are significantly associated with respiratory symptoms and non-allergic asthma but not with allergic asthma, and no significant relationship was observed between Hs CRP and allergic asthma or bronchial responsiveness.