H
Hafdis T. Helgadottir
Researcher at Amgen
Publications - 4
Citations - 1201
Hafdis T. Helgadottir is an academic researcher from Amgen. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 4, co-authored 4 publications receiving 1041 citations.
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Journal ArticleDOI
Large-scale whole-genome sequencing of the Icelandic population
Daniel F. Gudbjartsson,Hannes Helgason,Sigurjon A. Gudjonsson,Florian Zink,Asmundur Oddson,Arnaldur Gylfason,Søren Besenbacher,Gisli Magnusson,Bjarni V. Halldorsson,Eirikur Hjartarson,Gunnar Th. Sigurdsson,Simon N. Stacey,Michael L. Frigge,Hilma Holm,Jona Saemundsdottir,Hafdis T. Helgadottir,Hrefna Johannsdottir,Gunnlaugur Sigfússon,Gudmundur Thorgeirsson,Jon Th. Sverrisson,Solveig Gretarsdottir,G. Bragi Walters,Thorunn Rafnar,Bjarni Thjodleifsson,Einar Björnsson,Sigurdur Olafsson,Hildur Thorarinsdottir,Thora Steingrimsdottir,Thora S. Gudmundsdottir,Ásgeir Theodórs,Jon G. Jonasson,Asgeir Sigurdsson,Gyda Bjornsdottir,Jon J. Jonsson,Ólafur Thorarensen,Petur Ludvigsson,Hakon Gudbjartsson,Gudmundur I. Eyjolfsson,Olof Sigurdardottir,Isleifur Olafsson,David O. Arnar,Olafur Th Magnusson,Augustine Kong,Gisli Masson,Unnur Thorsteinsdottir,Agnar Helgason,Patrick Sulem,Kari Stefansson +47 more
TL;DR: The insights gained from sequencing the whole genomes of Icelanders to a median depth of 20× provide a study design that can be used to determine how variation in the sequence of the human genome gives rise to human diversity.
Journal ArticleDOI
Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes
Valgerdur Steinthorsdottir,Gudmar Thorleifsson,Patrick Sulem,Hannes Helgason,Niels Grarup,Asgeir Sigurdsson,Hafdis T. Helgadottir,Hrefna Johannsdottir,Olafur Th Magnusson,Sigurjon A. Gudjonsson,Johanne Marie Justesen,Marie Neergaard Harder,Marit E. Jørgensen,Cramer Christensen,Ivan Brandslund,Annelli Sandbæk,Torsten Lauritzen,Henrik Vestergaard,Allan Linneberg,Torben Jørgensen,Torben Jørgensen,Torben Jørgensen,Torben Hansen,Maryam S. Daneshpour,Mohammad-Sadegh Fallah,Astradur B. Hreidarsson,Gunnar Sigurdsson,Fereidoun Azizi,Rafn Benediktsson,Gisli Masson,Agnar Helgason,Augustine Kong,Daniel F. Gudbjartsson,Oluf Pedersen,Unnur Thorsteinsdottir,Kari Stefansson +35 more
TL;DR: Through whole-genome sequencing of 2,630 Icelanders and imputation into 11,114 Icelandic cases and 267,140 controls followed by testing in Danish and Iranian samples, 4 previously unreported variants affecting risk of type 2 diabetes (T2D) are discovered.
Journal ArticleDOI
HLA class II sequence variants influence tuberculosis risk in populations of European ancestry
Gardar Sveinbjornsson,Gardar Sveinbjornsson,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Bjarni V. Halldorsson,Bjarni V. Halldorsson,Karl G. Kristinsson,Magnus Gottfredsson,Jeffrey C. Barrett,Larus J. Gudmundsson,Kai Blöndal,Arnaldur Gylfason,Sigurjon A. Gudjonsson,Hafdis T. Helgadottir,Adalbjorg Jonasdottir,Aslaug Jonasdottir,Ari Karason,Ljiljana Bulat Kardum,Jelena Knežević,Helgi Kristjansson,Helgi Kristjansson,Mar Kristjansson,Arthur Löve,Arthur Löve,Yang Luo,Olafur Th Magnusson,Patrick Sulem,Augustine Kong,Gisli Masson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Zlatko Dembic,Sergey Nejentsev,Thorsteinn Blondal,Ingileif Jonsdottir,Ingileif Jonsdottir,Ingileif Jonsdottir,Kari Stefansson,Kari Stefansson +38 more
TL;DR: Findings show that the HLA class II region contributes to genetic risk of tuberculosis, possibly through reduced presentation of protective M. tuberculosis antigens to T cells.
Journal ArticleDOI
Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies
Cristina Rodriguez-Fontenla,Manuel Calaza,Evangelos Evangelou,Evangelos Evangelou,Ana M. Valdes,Nigel K Arden,Francisco J. Blanco,Andrew Carr,Karen E. Chapman,Panagiotis Deloukas,Michael Doherty,Tõnu Esko,C M Garcés Aletá,J J Gomez-Reino Carnota,Hafdis T. Helgadottir,Albert Hofman,I. Jonsdottir,Hanneke J. M. Kerkhof,Margreet Kloppenburg,Andrew McCaskie,Evangelia E. Ntzani,W. E. R. Ollier,Natividad Oreiro,Kalliope Panoutsopoulou,Stuart H. Ralston,Yolande F. M. Ramos,Javier Riancho,Fernando Rivadeneira,P.E. Slagboom,Unnur Styrkarsdottir,U. Thorsteinsdottir,Gudmar Thorleifsson,Aspasia Tsezou,André G. Uitterlinden,Gillian A. Wallis,Jeremy Mark Wilkinson,Guangju Zhai,Yanyan Zhu,David T. Felson,John P. A. Ioannidis,John P. A. Ioannidis,John Loughlin,Andres Metspalu,Ingrid Meulenbelt,Kari Stefansson,J.B. van Meurs,Eleftheria Zeggini,Tim D. Spector,Antonio Gonzalez +48 more
TL;DR: To assess candidate genes for association with osteoarthritis (OA) and identify promising genetic factors and, secondarily, to assess the candidate gene approach in OA.