B
Bjoern Schwer
Researcher at University of California, San Francisco
Publications - 46
Citations - 7882
Bjoern Schwer is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: DNA repair & Sirtuin. The author has an hindex of 26, co-authored 42 publications receiving 7002 citations. Previous affiliations of Bjoern Schwer include Boston Children's Hospital & Gladstone Institutes.
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Journal ArticleDOI
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Matthew D. Hirschey,Tadahiro Shimazu,Tadahiro Shimazu,Eric S. Goetzman,Enxuan Jing,Bjoern Schwer,Bjoern Schwer,Bjoern Schwer,David B. Lombard,Carrie A. Grueter,Charles A. Harris,Sudha B. Biddinger,Olga Ilkayeva,Robert Stevens,Yu Li,Asish K. Saha,Neil B. Ruderman,James R. Bain,Christopher B. Newgard,Robert V. Farese,Frederick W. Alt,C. Ronald Kahn,Eric Verdin,Eric Verdin +23 more
TL;DR: It is demonstrated that SIRT3 modulates mitochondrial intermediary metabolism and fatty-acid use during fasting and acetylation is identified as a novel regulatory mechanism for mitochondrial fatty- acid oxidation.
Journal ArticleDOI
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
David B. Lombard,Frederick W. Alt,Hwei Ling Cheng,Jakob Bunkenborg,Ryan S. Streeper,Raul Mostoslavsky,Jennifer Kim,George D. Yancopoulos,David M. Valenzuela,Andrew J. Murphy,Yinhua Yang,Yaohui Chen,Matthew D. Hirschey,Roderick T. Bronson,Marcia C. Haigis,Leonard Guarente,Robert V. Farese,Sherman M. Weissman,Eric Verdin,Bjoern Schwer,Bjoern Schwer +20 more
TL;DR: It is demonstrated that SIRT3 has evolved to control reversible lysine acetylation in this organelle and is shown to be a soluble mitochondrial protein.
Journal ArticleDOI
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
Matthew D. Hirschey,Tadahiro Shimazu,Enxuan Jing,Carrie A. Grueter,Amy M. Collins,Bradley E. Aouizerat,Alena Stančáková,Eric S. Goetzman,Maggie Lam,Bjoern Schwer,Robert Stevens,Michael J. Muehlbauer,Sanjay Kakar,Nathan M. Bass,Johanna Kuusisto,Markku Laakso,Frederick W. Alt,Frederick W. Alt,Christopher B. Newgard,Robert V. Farese,C. Ronald Kahn,Eric Verdin +21 more
TL;DR: It is found that high-fat diet (HFD) feeding induces hepatic mitochondrial protein hyperacetylation in mice and downregulation of the major mitochondrial protein deacetylase SIRT3, which contributes to the metabolic syndrome.
Journal ArticleDOI
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2.
TL;DR: The findings show that a mammalian sirtuin directly controls the activity of a metabolic enzyme by means of reversible lysine acetylation, and highlights the conservation of a metabolism regulatory pathway from bacteria to humans.
Journal ArticleDOI
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.
Tadahiro Shimazu,Matthew D. Hirschey,Lan Hua,Kristin E. Dittenhafer-Reed,Bjoern Schwer,David B. Lombard,Yu Li,Jakob Bunkenborg,Frederick W. Alt,John M. Denu,Matthew P. Jacobson,Eric Verdin +11 more
TL;DR: Findings show SIRT3 regulates ketone body production during fasting and provide molecular insight into how protein acetylation can regulate enzymatic activity.