B
Blanche Capel
Researcher at Duke University
Publications - 152
Citations - 18566
Blanche Capel is an academic researcher from Duke University. The author has contributed to research in topics: Gonad & Testis determining factor. The author has an hindex of 63, co-authored 146 publications receiving 16855 citations. Previous affiliations of Blanche Capel include National Institute for Medical Research & Fox Chase Cancer Center.
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Journal ArticleDOI
A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes
John Gubbay,Jérôme Collignon,Peter Koopman,Blanche Capel,Androulla Economou,Andrea Münsterberg,Nigel Vivian,Peter N. Goodfellow,Robin Lovell-Badge +8 more
TL;DR: A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination.
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Circular transcripts of the testis-determining gene Sry in adult mouse testis
Blanche Capel,Amanda Swain,Silvia K. Nicolis,Adam Hacker,Michael A. Walter,Peter Koopman,Peter N. Goodfellow,Robin Lovell-Badge +7 more
TL;DR: It is suggested that the circles arise from normal splicing processes as a consequence of the unusual genomic structure surrounding the Sry locus in the mouse.
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Retinoic acid regulates sex-specific timing of meiotic initiation in mice.
TL;DR: In this paper, the authors examined the mechanism underlying the sex-specific timing of Stra8 expression and meiotic initiation in mice and showed that signaling by retinoic acid (RA), an active derivative of vitamin A, is required for Stra8expression and thereby meiosis initiation in embryonic ovaries.
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Expression of a candidate sex-determining gene during mouse testis differentiation
TL;DR: The observations strongly support a primary role for Sry in mouse sex determination, and further the involvement of this gene, Sry, in testis development, which is studied in detail.
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Expression of Sry, the mouse sex determining gene
TL;DR: This work uses RNase protection to map the extent of the less abundant Sry transcript in the developing gonad and demonstrates that it is a linear mRNA derived from a single exon, which defines the critical period during which Sry must act to initiate Sertoli cell differentiation.