Bo Chen

TL;DR: Evidence is provided that HDAC4 plays an important role in promoting the survival of retinal neurons and relied at least partly on the activity of hypoxia-inducible factor 1α (HIF1α) in the cytoplasm.

TL;DR: Evidence of vision restoration after de novo MG-derived genesis of rod photoreceptors in mammalian retinas is provided, following gene transfer of β-catenin, cell-cycle-reactivated MG can be reprogrammed to generate rod photoresceptors by subsequent geneTransfer of transcription factors essential for rod cell fate specification and determination.

TL;DR: It is shown that gene transfer of β-catenin in adult mouse retinas activates Wnt signaling and MG proliferation without retinal injury, and it is demonstrated that let-7 miRNAs are critically involved in Wnt/Lin28-regulated MG proliferation.

TL;DR: It is shown that perturbing the cholesterol/sphingomyelin balance in the plasma membrane results in the massive formation of clusters of narrow endocytic tubular invaginations positive for N-BAR proteins, which support a role for sphingosine phosphorylation inendocytic membrane trafficking beyond the established function of sphingoine-1-phosphate in intercellular signalling.

TL;DR: In Group A rats that were followed sequentially, all the ERG parameters recorded with attenuated stimuli showed significant time-dependent changes in glaucomatous eyes relative to their contralateral normal eyes, with OPs showing the earliest significant difference after only 3 weeks of high IOP.