B
Bo Dupont
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 235
Citations - 18658
Bo Dupont is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Human leukocyte antigen & Antigen. The author has an hindex of 71, co-authored 235 publications receiving 18195 citations. Previous affiliations of Bo Dupont include Cornell University & University of Zurich.
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Journal ArticleDOI
Structure of human steroid 21-hydroxylase genes
TL;DR: If this cytochrome P-450 enzyme is defective, cortisol cannot be synthesized, resulting in congenital adrenal hyperplasia, and the 21-OHase A gene is, therefore, a pseudogene.
Journal Article
High frequency of nonclassical steroid 21-hydroxylase deficiency.
TL;DR: In this article, the authors used HLA-B genotype data in families containing multiple members affected with nonclassical 21-hydroxylase deficiency together with the results of quantitative hormonal tests to arrive at estimates of gene and disease frequencies for this disorder.
Journal ArticleDOI
High Frequency of Nonclassical Steroid 21-Hydroxylase Deficiency
TL;DR: HLA-B genotype data in families containing multiple members affected with nonclassical 21-hydroxylase deficiency is used together with the results of quantitative hormonal tests to arrive at estimates of gene and disease frequencies for this disorder.
Journal ArticleDOI
Transplantation for severe combined immunodeficiency with HLA-A,B,D,DR incompatible parental marrow cells fractionated by soybean agglutinin and sheep red blood cells.
Yair Reisner,Kapoor N,D Kirkpatrick,Pollack,Susanna Cunningham-Rundles,Bo Dupont,MZ Hodes,Robert A. Good,R.J. O'Reilly +8 more
TL;DR: This article showed that depletion of T lymphocytes by this technique can abrogate the potential of histoincompatible marrow grafts to induce lethal GVHD without limiting immunologic reconstitution.
Journal ArticleDOI
Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man
Perrin C. White,Dario Grossberger,Barbara J. Onufer,David D. Chaplin,Maria I. New,Bo Dupont,Jack L. Strominger +6 more
TL;DR: Two genes encoding steroid 21-hydroxylase, a cytochrome P-450 enzyme, have been located within the HLA major histocompatibility complex, and restriction mapping and hybridization analysis showed that there are two 21-OHase genes, each located near the 3' end of one of the two C4 genes.