Bolong Xu

TL;DR: In this paper, a single-atom nanozyme (SAzyme) based on a zinc-based zeolitic-imidazolate-framework (ZIF-8)-derived carbon nanomaterial containing atomically dispersed zinc atoms was investigated.

TL;DR: The superior sonosensitization effect of PMCS is believed to be closely linked to the porphyrin-like macrocycle in MOF-derived nanostructure in comparison to amorphous carbon nanospheres, due to their large highest occupied molecular orbital (HOMO) gap for high reactive oxygen species (ROS) production.

TL;DR: A novel nanozyme (PtFe@Fe3O4) with dual enzyme-like activities for highly efficient tumor catalytic therapy shows the intrinsic photothermal effect as well as photo-enhanced peroxidase-like and catalase- like activities in the acidic TME, thereby effectively killing tumor cells and overcoming the tumor hypoxia.

TL;DR: It is demonstrated that both IMSN and TI can regulate the tumor immune microenvironment, resulting in macrophage polarization from M2 to M1, and thus inducing the regeneration of H2O2, which can promote catalytic activities of IMSN nanozyme.

TL;DR: In vitro and in vivo studies indicate that the single-component H-Pd NSs can act as a photothermal/photodynamic agent for imaging-guided hypoxic tumor therapy, with a high tumor inhibition rate of 99.7%.