S
Smitha Shankar
Researcher at Center for Infectious Disease Research and Policy
Publications - 10
Citations - 1466
Smitha Shankar is an academic researcher from Center for Infectious Disease Research and Policy. The author has contributed to research in topics: Tuberculosis & Mycobacterium tuberculosis. The author has an hindex of 9, co-authored 10 publications receiving 1071 citations.
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Journal ArticleDOI
A blood RNA signature for tuberculosis disease risk: a prospective cohort study.
Daniel E. Zak,Adam Penn-Nicholson,Thomas J. Scriba,Ethan G. Thompson,Sara Suliman,Lynn M. Amon,Hassan Mahomed,Mzwandile Erasmus,Wendy Whatney,Gregory D. Hussey,Deborah Abrahams,Fazlin Kafaar,Tony Hawkridge,Suzanne Verver,E. Jane Hughes,Martin O. C. Ota,Jayne S. Sutherland,Rawleigh Howe,Hazel M. Dockrell,W. Henry Boom,Bonnie Thiel,Tom H. M. Ottenhoff,Harriet Mayanja-Kizza,Amelia C. Crampin,Katrina Downing,Mark Hatherill,Joe Valvo,Smitha Shankar,Shreemanta K. Parida,Stefan H. E. Kaufmann,Gerhard Walzl,Alan Aderem,Willem A. Hanekom +32 more
TL;DR: The whole blood tuberculosis risk signature prospectively identified people at risk of developing active tuberculosis, opening the possibility for targeted intervention to prevent the disease.
Journal ArticleDOI
Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis
Sara Suliman,Ethan G. Thompson,Jayne S. Sutherland,January Weiner rd,Martin O. C. Ota,Smitha Shankar,Adam Penn-Nicholson,Adam Penn-Nicholson,Bonnie Thiel,Mzwandile Erasmus,Mzwandile Erasmus,Jeroen Maertzdorf,Fergal J. Duffy,Philip C. Hill,E. Jane Hughes,E. Jane Hughes,Kim Stanley,Katrina Downing,Katrina Downing,Michelle Fisher,Michelle Fisher,Joe Valvo,Shreemanta K. Parida,Gian D. van der Spuy,Gian D. van der Spuy,Gerard Tromp,Gerard Tromp,Ifedayo M. O. Adetifa,Simon Donkor,Rawleigh Howe,Harriet Mayanja-Kizza,W. Henry Boom,Hazel M. Dockrell,Tom H. M. Ottenhoff,Mark Hatherill,Mark Hatherill,Alan Aderem,Willem A. Hanekom,Willem A. Hanekom,Thomas J. Scriba,Thomas J. Scriba,Stefan H. E. Kaufmann,Daniel E. Zak,Gerhard Walzl,Gerhard Walzl +44 more
TL;DR: A simple whole blood‐based PCR test to predict TB in recently exposed household contacts from diverse African populations has potential for implementation in national TB contact investigation programs.
Journal ArticleDOI
Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine.
Scott G. Hansen,Daniel E. Zak,Guangwu Xu,Julia C. Ford,Emily E. Marshall,Daniel Malouli,Roxanne M. Gilbride,Colette M. Hughes,Abigail B. Ventura,Emily Ainslie,Kurt T. Randall,Andrea N. Selseth,Parker Rundstrom,Lauren Herlache,Matthew S. Lewis,Haesun Park,Shannon L. Planer,John M. Turner,Miranda Fischer,Christina Armstrong,Robert C. Zweig,Joseph Valvo,Jackie Braun,Smitha Shankar,Lenette L. Lu,Andrew W. Sylwester,Alfred W. Legasse,Martin Messerle,Michael A. Jarvis,Lynn M. Amon,Alan Aderem,Galit Alter,Dominick Laddy,Michele Stone,Aurelio Bonavia,Thomas G. Evans,Michael K. Axthelm,Klaus Früh,Paul T. Edlefsen,Louis J. Picker +39 more
TL;DR: The results suggest that complete vaccine-mediated immune control of highly pathogenic Mtb is possible if immune effector responses can intercept Mtb infection at its earliest stages.
Journal ArticleDOI
Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease.
Thomas J. Scriba,Adam Penn-Nicholson,Smitha Shankar,Thomas Hraha,Ethan G. Thompson,David Sterling,Elisa Nemes,Fatoumatta Darboe,Sara Suliman,Lynn M. Amon,Hassan Mahomed,Mzwandile Erasmus,Wendy Whatney,John L. Johnson,W. Henry Boom,Mark Hatherill,Joe Valvo,Mary Ann De Groote,Urs A. Ochsner,Alan Aderem,Willem A. Hanekom,Daniel E. Zak +21 more
TL;DR: A timeline to the different immunological stages of disease progression which comprise sequential inflammatory dynamics and immune alterations that precede disease manifestations and diagnosis of tuberculosis disease is provided.
Journal ArticleDOI
Host blood RNA signatures predict the outcome of tuberculosis treatment
Ethan G. Thompson,Ying Du,Stephanus T. Malherbe,Smitha Shankar,Jackie Braun,Joe Valvo,Katharina Ronacher,Gerard Tromp,David L. Tabb,David Alland,Shubhada Shenai,Laura E. Via,James M. Warwick,Alan Aderem,Thomas J. Scriba,Jill Winter,Gerhard Walzl,Daniel E. Zak +17 more
TL;DR: A five-gene real-time PCR-based signature was developed that captures the clinically relevant responses to TB treatment and provides a convenient platform for stratifying patients according to their risk of treatment failure, and can complement sputum-based Gene Xpert for patient stratification, providing a rapid and accurate alternative to current methods.