B
Boris Steipe
Researcher at University of Toronto
Publications - 59
Citations - 4099
Boris Steipe is an academic researcher from University of Toronto. The author has contributed to research in topics: Green fluorescent protein & Fluorescence. The author has an hindex of 29, co-authored 54 publications receiving 3938 citations. Previous affiliations of Boris Steipe include Roche Diagnostics & Max Planck Society.
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The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data.
Henning Hermjakob,Luisa Montecchi-Palazzi,Gary D. Bader,Jérôme Wojcik,Lukasz Salwinski,Arnaud Ceol,Susan Moore,Sandra Orchard,Ugis Sarkans,Christian von Mering,Bernd Roechert,Sylvain Poux,Eva Jung,Henning Mersch,Paul J. Kersey,Michael Lappe,Yixue Li,Rong Zeng,Debashis Rana,Macha Nikolski,Holger Husi,Christine Brun,K. Shanker,Seth G. N. Grant,Chris Sander,Peer Bork,Weimin Zhu,Akhilesh Pandey,Alvis Brazma,Bernard Jacq,Marc Vidal,David James Sherman,Pierre Legrain,Gianni Cesareni,Ioannis Xenarios,David Eisenberg,Boris Steipe,Christopher W. V. Hogue,Rolf Apweiler +38 more
TL;DR: This work proposes a community standard data model for the representation and exchange of protein interaction data, jointly developed by members of the Proteomics Standards Initiative (PSI) and the Human Proteome Organization (HUPO).
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High‐level Biosynthetic Substitution of Methionine in Proteins by its Analogs 2‐Aminohexanoic Acid, Selenomethionine, Telluromethionine and Ethionine in Escherichia coli
Nediljko Budisa,Boris Steipe,Boris Steipe,Pascal Demange,Christoph Eckerskorn,Josef Kellermann,Robert Huber +6 more
TL;DR: This work describes the first biosynthetic high-level substitution of methionine by 2-aminohexanoic acid (norleucine), ethionine and telluromethionine in a protein, and confirms the replacement has been confirmed by electrospray mass spectroscopy, amino acid analysis and X-ray structural analysis.
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Sequence statistics reliably predict stabilizing mutations in a protein domain.
TL;DR: Analyzing constraints in the conceptual framework of statistical mechanics is able to predict stabilizing mutations in the McPC603 V kappa domain from sequence information alone with better than 60% success rate and may be generalized to engineer other proteins for higher stability.
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ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy
TL;DR: It is shown that elongated mitochondria are more resistant to ROS-induced damage and mitophagy compared with fragmented mitochondria, suggesting that mitochondrial morphology has an important role in regulating ROS andMitophagy.
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Crystal structure of P22 tailspike protein: interdigitated subunits in a thermostable trimer.
TL;DR: The tailspike protein of Salmonella typhimurium phage P22 is a part of the apparatus by which the phage attaches to the bacterial host and hydrolyzes the O antigen and has served as a model system for genetic and biochemical analysis of protein folding.