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Brandon C. Knott
Researcher at National Renewable Energy Laboratory
Publications - 31
Citations - 1656
Brandon C. Knott is an academic researcher from National Renewable Energy Laboratory. The author has contributed to research in topics: Nucleation & Reaction coordinate. The author has an hindex of 17, co-authored 30 publications receiving 1167 citations. Previous affiliations of Brandon C. Knott include United States Department of Energy & University of California, Santa Barbara.
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Journal ArticleDOI
Homogeneous nucleation of methane hydrates: unrealistic under realistic conditions.
TL;DR: It is found that critical nuclei are extremely large and that homogeneous nucleation rates are extremely low, suggesting that nucleation of methane hydrates under these realistic conditions cannot occur by a homogeneous mechanism.
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Characterization and engineering of a two-enzyme system for plastics depolymerization.
Brandon C. Knott,Erika Erickson,Mark D. Allen,Japheth E. Gado,Rosie Graham,Fiona L. Kearns,Isabel Pardo,Ece Topuzlu,Jared J. Anderson,Harry P. Austin,Graham Dominick,Christopher W. Johnson,Nicholas A. Rorrer,Caralyn J. Szostkiewicz,Valérie Copié,Christina M. Payne,H. Lee Woodcock,Bryon S. Donohoe,Gregg T. Beckham,John McGeehan +19 more
TL;DR: The characterization of the MHETase enzyme and synergy of the two-enzyme PET depolymerization system may inform enzyme cocktail-based strategies for plastics upcycling and will inform future efforts in the biological deconstruction andUpcycling of mixed plastics.
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The Mechanism of Cellulose Hydrolysis by a Two-Step, Retaining Cellobiohydrolase Elucidated by Structural and Transition Path Sampling Studies.
Brandon C. Knott,Majid Haddad Momeni,Michael F. Crowley,Lloyd F. Mackenzie,Andreas W. Götz,Mats Sandgren,Stephen G. Withers,Jerry Ståhlberg,Gregg T. Beckham +8 more
TL;DR: Two new structures of the catalytic domain of Hypocrea jecorina GH Family 7 cellobiohydrolase Cel7A are presented, namely a Michaelis complex with a full cellononaose ligand and a glycosyl-enzyme intermediate, that reveal details of the 'static' reaction coordinate.
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Consideration of the Aluminum Distribution in Zeolites in Theoretical and Experimental Catalysis Research
Brandon C. Knott,Claire T. Nimlos,David J. Robichaud,Mark R. Nimlos,Seonah Kim,Rajamani Gounder +5 more
TL;DR: In this paper, the authors describe how active-site distributions affect catalysis and provide a molecular-level description of the structure and behavior of the zeolite materials under interrogation.
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Carbohydrate–Protein Interactions That Drive Processive Polysaccharide Translocation in Enzymes Revealed from a Computational Study of Cellobiohydrolase Processivity
TL;DR: Simulation is employed to examine how a cellulose chain translocates by a disaccharide unit during the processive cycle of a glycoside hydrolase family 7 cellobiohydrolase, and suggests that the rate-limiting step in enzymatic cellulose degradation is the glycosylation reaction, not chain processivity.