F
Fiona L. Kearns
Researcher at University of South Florida
Publications - 22
Citations - 1242
Fiona L. Kearns is an academic researcher from University of South Florida. The author has contributed to research in topics: Docking (molecular) & QM/MM. The author has an hindex of 9, co-authored 19 publications receiving 552 citations. Previous affiliations of Fiona L. Kearns include University of California, San Diego & Eckerd College.
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Journal ArticleDOI
Characterization and engineering of a plastic-degrading aromatic polyesterase
Harry P. Austin,Mark D. Allen,Bryon S. Donohoe,Nicholas A. Rorrer,Fiona L. Kearns,Rodrigo L. Silveira,Rodrigo L. Silveira,Benjamin C. Pollard,Graham Dominick,Ramona Duman,Kamel El Omari,Vitaliy Mykhaylyk,Armin Wagner,William E. Michener,Antonella Amore,Munir S. Skaf,Michael F. Crowley,Alan W. Thorne,Christopher W. Johnson,H. Lee Woodcock,John McGeehan,Gregg T. Beckham +21 more
TL;DR: 3D structure of a newly discovered enzyme that can digest highly crystalline PET, the primary material used in the manufacture of single-use plastic beverage bottles, in some clothing, and in carpets is characterized and it is shown that PETase degrades another semiaromatic polyester, polyethylene-2,5-furandicarboxylate (PEF), which is an emerging, bioderived PET replacement with improved barrier properties.
Journal ArticleDOI
Characterization and engineering of a two-enzyme system for plastics depolymerization.
Brandon C. Knott,Erika Erickson,Mark D. Allen,Japheth E. Gado,Rosie Graham,Fiona L. Kearns,Isabel Pardo,Ece Topuzlu,Jared J. Anderson,Harry P. Austin,Graham Dominick,Christopher W. Johnson,Nicholas A. Rorrer,Caralyn J. Szostkiewicz,Valérie Copié,Christina M. Payne,H. Lee Woodcock,Bryon S. Donohoe,Gregg T. Beckham,John McGeehan +19 more
TL;DR: The characterization of the MHETase enzyme and synergy of the two-enzyme PET depolymerization system may inform enzyme cocktail-based strategies for plastics upcycling and will inform future efforts in the biological deconstruction andUpcycling of mixed plastics.
Journal ArticleDOI
A glycan gate controls opening of the SARS-CoV-2 spike protein.
Terra Sztain,Surl-Hee Ahn,Anthony T. Bogetti,Lorenzo Casalino,Jory A. Goldsmith,Evan Seitz,Ryan S McCool,Fiona L. Kearns,Francisco Acosta-Reyes,Suvrajit Maji,Ghoncheh Mashayekhi,J. Andrew McCammon,Abbas Ourmazd,Joachim Frank,Joachim Frank,Jason S. McLellan,Lillian T. Chong,Rommie E. Amaro +17 more
TL;DR: In this paper, a gating role for the N-glycan at position N343 is revealed, which facilitates RBD opening, along with residuals D405, R408 and D427.
Posted ContentDOI
A glycan gate controls opening of the SARS-CoV-2 spike protein
Terra Sztain,Surl-Hee Ahn,Anthony T. Bogetti,Lorenzo Casalino,Jory A. Goldsmith,Ryan S McCool,Fiona L. Kearns,J. Andrew McCammon,Jason S. McLellan,Lillian T. Chong,Rommie E. Amaro +10 more
TL;DR: In this article, a gating role for the N-glycan at position N343 was revealed, which facilitates RBD opening, and the atomic-level characterization of the glycosylated spike activation mechanism provided by the ensemble pathway simulations.
Posted ContentDOI
#COVIDisAirborne: AI-Enabled Multiscale Computational Microscopy of Delta SARS-CoV-2 in a Respiratory Aerosol
Abigail C. Dommer,Lorenzo Casalino,Fiona L. Kearns,Mia Rosenfeld,Nicholas Wauer,Surl-Hee Ahn,John D. Russo,Sofia Oliveira,Clare Morris,Anthony T. Bogetti,Anda Trifan,Alexander Brace,Terra Sztain,Austin Clyde,Heng Ma,Chakra Chennubhotla,Hyungro Lee,Matteo Turilli,Syma Khalid,Teresa Tamayo-Mendoza,Matthew Welborn,Anders Christiansen,Daniel G. A. Smith,Zhuoran Qiao,Sai Krishna Sirumalla,Frederick R. Manby,Animashree Anandkumar,David J. Hardy,James Phillips,Abraham C. Stern,Josh Romero,David Clark,Mitchell Dorrell,Tom Maiden,Lei Huang,John McCalpin,Christopher Woods,Alan Gray,Matt Williams,Bryan Barker,Harinda Rajapaksha,Richard Pitts,Tom Gibbs,John E. Stone,Daniel M. Zuckerman,Adrian Muholland,Thomas F. Miller,Shantenu Jha,Arvind Ramanathan,Lillian T. Chong,Rommie E. Amaro +50 more
TL;DR: Dommer et al. as discussed by the authors proposed a multiscale computational microscopy of the SARS-CoV-2 virus within a respiratory aerosol and demonstrated how their integrated data-driven platform provides a new way of exploring the composition, structure, and dynamics of aerosols and aerosolized viruses.