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Brandon J. Metge
Researcher at University of Alabama at Birmingham
Publications - 34
Citations - 1742
Brandon J. Metge is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Breast cancer & Metastasis. The author has an hindex of 17, co-authored 29 publications receiving 1477 citations. Previous affiliations of Brandon J. Metge include University of South Alabama.
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Journal ArticleDOI
The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis
Adam I. Riker,Steven A. Enkemann,Øystein Fodstad,Suhu Liu,Suping Ren,Christopher G. Morris,Yaguang Xi,Paul Howell,Brandon J. Metge,Rajeev S. Samant,Lalita A. Shevde,Wenbin Li,Steven A. Eschrich,Adil Daud,Jingfang Ju,Jaime Matta +15 more
TL;DR: The gene expression profiling of primary, non-metastatic cutaneous tumors and metastatic melanoma has resulted in the identification of several genes that may be centrally involved in the progression and metastasis potential of melanoma.
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Identification of Differentially Secreted Biomarkers using LC-MS/MS in Isogenic Cell Lines Representing a Progression of Breast Cancer
TL;DR: The protein with consistent association with aggressiveness in all lines, and in unrelated cancer cells, was the galectin-3-binding protein which has been associated with breast, prostate, and colon cancer earlier, supporting the approach and findings.
Journal ArticleDOI
Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-κB activation
Rajeev S. Samant,David W. Clark,Rebecca A. Fillmore,Muzaffer Cicek,Brandon J. Metge,Kondethimmana H Chandramouli,Ann F. Chambers,Graham Casey,Danny R. Welch,Lalita A. Shevde +9 more
TL;DR: OPN, a tumor-metastasis activator, is identified as a crucial downstream target of BRMS1, and a role of HDAC3 in suppression of OPN via OPN/NF-κB is shown.
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The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin.
Shamik Das,Lillianne G. Harris,Brandon J. Metge,Suhu Liu,Adam I. Riker,Rajeev S. Samant,Lalita A. Shevde +6 more
TL;DR: This study reports that expression of GLI1 and osteopontin increase progressively with the progression of melanoma from primary cutaneous cancer to metastatic melanoma in clinically derived specimens, and concludes that theGLI1-mediated up-regulation of OPN promotes malignant behavior of cancer cells.
Journal ArticleDOI
Osteopontin Knockdown Suppresses Tumorigenicity of Human Metastatic Breast Carcinoma, MDA-MB-435
Lalita A. Shevde,Lalita A. Shevde,Rajeev S. Samant,Rajeev S. Samant,Jason C. Paik,Brandon J. Metge,Ann F. Chambers,Graham Casey,Andra R. Frost,Danny R. Welch,Danny R. Welch +10 more
TL;DR: Functional evidence is provided that OPN contributes to breast tumor growth as well, in addition to the widely reported roles of OPN in late stages of tumor progression.