Rajeev S. Samant

TL;DR: The gene expression profiling of primary, non-metastatic cutaneous tumors and metastatic melanoma has resulted in the identification of several genes that may be centrally involved in the progression and metastasis potential of melanoma.

TL;DR: The inhibitory effects of niclosamide on cancer stem cells provide further evidence for its consideration as a promising drug for cancer therapy.

TL;DR: The isolation and functional characterization of a full-length cDNA for one of the novel genes, designated breast-cancer metastasis suppressor 1 (BRMS1), which maps to human chromosome 11q13.1-q 13.2 provides compelling functional evidence that breast- cancer metastasis suppression 1 is a novel mediator of metastasis suppressed in human breast carcinoma.

TL;DR: A broad perspective is provided on the importance of OPN in the pathophysiology of cancer to be a crucial mediator of cellular cross talk and an influential factor in the tumor microenvironment.

TL;DR: Deletion analyses show that the carboxyl-terminal 42 amino acids of BRMS1 are not critical for interaction with much of the mSin3 complex and that BR MS1 appears to have more than one binding point to the complex, and suggest a novel mechanism by whichBRMS1 might suppress cancer metastasis.