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Brent T. Harris
Researcher at Georgetown University Medical Center
Publications - 153
Citations - 7304
Brent T. Harris is an academic researcher from Georgetown University Medical Center. The author has contributed to research in topics: Protoporphyrin IX & Amyotrophic lateral sclerosis. The author has an hindex of 43, co-authored 147 publications receiving 6089 citations. Previous affiliations of Brent T. Harris include Drexel University & Dartmouth–Hitchcock Medical Center.
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Journal ArticleDOI
Formation of native prions from minimal components in vitro.
TL;DR: Results show that prions able to infect wild-type hamsters can be formed from a minimal set of components including native PrPC molecules, copurified lipid molecules, and a synthetic polyanion.
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Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer
David A. Solomon,Taeyeon Kim,Laura A. Díaz-Martínez,Joshlean Fair,Abdel G. Elkahloun,Brent T. Harris,Jeffrey A. Toretsky,Steven A. Rosenberg,Neerav Shukla,Marc Ladanyi,Yardena Samuels,C. David James,Hongtao Yu,Jung-Sik Kim,Todd Waldman +14 more
TL;DR: Studying a near-diploid human cell line with a stable karyotype, it is found that targeted inactivation of STAG2 led to chromatid cohesion defects and aneuploidy, whereas in two aneuPLoid human glioblastoma cell lines, targeted correction of the endogenous mutant alleles of STAE led to enhanced chromosomal stability.
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Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker.
Pablo A. Valdés,Frederic Leblond,Anthony Kim,Brent T. Harris,Brian C. Wilson,Xiaoyao Fan,Tor D. Tosteson,Alex Hartov,Songbai Ji,Kadir Erkmen,Kadir Erkmen,Nathan E. Simmons,Nathan E. Simmons,Keith D. Paulsen,David W. Roberts,David W. Roberts +15 more
TL;DR: This study is the first to measure quantitative ALA-induced PpIX concentrations in vivo, and the results have broad implications for guidance during resection of intracranial tumors.
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Engraftment of sorted/expanded human central nervous system stem cells from fetal brain
Stanley Tamaki,Karl Eckert,Dongping He,Richard E. Sutton,Monika Doshe,Gitanjali Jain,Robert Tushinski,Michael J. Reitsma,Brent T. Harris,Ann Tsukamoto,Fred H. Gage,Irving L. Weissman,Nobuko Uchida +12 more
TL;DR: Marking human CNS‐SC with reporter genes introduced by lentiviral vectors is a useful tool with which to characterize migration and differentiation of human cells in this mouse transplantation model.
Journal ArticleDOI
Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between δ-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article.
David W. Roberts,Pablo A. Valdés,Brent T. Harris,Kathryn Fontaine,Alexander Hartov,Alexander Hartov,Xiaoyao Fan,Songbai Ji,S. Scott Lollis,Brian W. Pogue,Brian W. Pogue,Frederic Leblond,Tor D. Tosteson,Tor D. Tosteson,Brian C. Wilson,Keith D. Paulsen,Keith D. Paulsen +16 more
TL;DR: The finding that preoperative MR image signatures are predictive of intraoperative PpIX fluorescence is of practical importance for identifying candidates for the procedure and provides evidence that a strong relationship exists between tumor aggressiveness and the degree of tissue fluorescence that is observable intraoperatively.