David A. Solomon

TL;DR: Studying a near-diploid human cell line with a stable karyotype, it is found that targeted inactivation of STAG2 led to chromatid cohesion defects and aneuploidy, whereas in two aneuPLoid human glioblastoma cell lines, targeted correction of the endogenous mutant alleles of STAE led to enhanced chromosomal stability.

TL;DR: It is shown that GSKJ4 pharmacologic inhibition of K27 demethylase JMJD3 increases cellular H3K27 methylation in K27M tumor cells and demonstrate potent antitumor activity both in vitro against K 27M cells and in vivo against K27m xenografts.

TL;DR: Working Committee 3 recommended that a substantial number of newly recognized types and subtypes should be considered for inclusion in future CNS tumor classifications.

TL;DR: The largest genomic survey to date of 101 EFT (65 tumors and 36 cell lines) is reported, finding that EFT has a very low mutational burden but frequent deleterious mutations in the cohesin complex subunit STAG2 and that 11% of tumors pathologically diagnosed as EFT lack a typical EWSR1 fusion oncogene and these tumors do not have a characteristic Ewing sarcoma gene expression signature.

TL;DR: A series of 47 diffuse midline gliomas with histone H3‐K27M mutation is described, involving 25 male and 22 female patients and centered not only in the pons, thalamus, and spinal cord, but also in the third ventricle, hypothalamus, pineal region and cerebellum.