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Brett E. Bouma
Researcher at Harvard University
Publications - 496
Citations - 52032
Brett E. Bouma is an academic researcher from Harvard University. The author has contributed to research in topics: Optical coherence tomography & Laser. The author has an hindex of 116, co-authored 474 publications receiving 49561 citations. Previous affiliations of Brett E. Bouma include Hope College & Lahey Hospital & Medical Center.
Papers
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Patent
Methods and apparatus for forward-directed optical scanning instruments
Stephen A. Boppart,Gary J. Tearney,Brett E. Bouma,Mark E. Brezinski,James G. Fujimoto,Eric A. Swanson +5 more
TL;DR: An imaging system for performing forward scanning imaging for application to therapeutic and diagnostic devises used in medical procedures is described in this article, which includes forward directed optical coherence tomography (OCT), and non-retroreflected forward scanning OCT.
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Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging.
Benjamin J. Vakoc,Ryan M. Lanning,Ryan M. Lanning,James Alex Tyrrell,Timothy P. Padera,Lisa A. Bartlett,Triantafyllos Stylianopoulos,Lance L. Munn,Guillermo J. Tearney,Guillermo J. Tearney,Dai Fukumura,Rakesh K. Jain,Brett E. Bouma,Brett E. Bouma +13 more
TL;DR: This work introduces optical frequency domain imaging (OFDI) as an intravital microscopy that circumvents the technical limitations of multiphoton microscopy and provides unprecedented access to previously unexplored, crucial aspects of tissue biology.
Journal ArticleDOI
Determination of the refractive index of highly scattering human tissue by optical coherence tomography.
Guillermo J. Tearney,Mark E. Brezinski,James F. Southern,Brett E. Bouma,Michael R. Hee,James G. Fujimoto +5 more
TL;DR: Two new techniques, based on optical coherence tomography (OCT), for determining the refractive index of highly scattering human tissue are described, using OCT to track the focal length shift that results from translating the focus along the optic axis within the tissue.
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In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve.
Nader Nassif,Barry Cense,Boris Hyle Park,Mark C. Pierce,Seok Hyun Yun,Brett E. Bouma,Guillermo J. Tearney,Teresa C. Chen,J. F. de Boer +8 more
TL;DR: 3-dimensional data sets were collected in 11 and 13 seconds for the macula and optic nerve head respectively and are presented to demonstrate the potential clinical applications of SD-OCT in ophthalmology.
Journal ArticleDOI
Optical Coherence Tomography for Optical Biopsy Properties and Demonstration of Vascular Pathology
Mark E. Brezinski,Guillermo J. Tearney,Brett E. Bouma,Joseph A. Izatt,Michael R. Hee,Eric A. Swanson,James F. Southern,James G. Fujimoto +7 more
TL;DR: OCT represents a promising new technology for imaging vascular microstructure with a level of resolution not previously achieved with the use of other imaging modalities, and can be performed with a catheter integrated with a relatively inexpensive optical fiber.