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Brett E. Bouma
Researcher at Harvard University
Publications - 496
Citations - 52032
Brett E. Bouma is an academic researcher from Harvard University. The author has contributed to research in topics: Optical coherence tomography & Laser. The author has an hindex of 116, co-authored 474 publications receiving 49561 citations. Previous affiliations of Brett E. Bouma include Hope College & Lahey Hospital & Medical Center.
Papers
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Journal ArticleDOI
Intraoperative assessment of microsurgery with three-dimensional optical coherence tomography.
Stephen A. Boppart,Brett E. Bouma,Costas Pitris,Gary J. Tearney,James F. Southern,Mark E. Brezinski,James C. Fujimoto +6 more
TL;DR: Three-dimensional, micrometer-scale, diagnostic imaging capabilities of OCT permit rapid feedback for assessment of microsurgical procedures and can be readily integrated with surgical microscopes and has potential for intraoperative monitoring to improve patient outcome.
Patent
Optical methods for tissue analysis
TL;DR: In this article, the authors proposed a method and system to optically analyze samples such as tissue based on speckle patterns of microscopic motion, such as Brownian motion, which relates to methods and systems for optically analyzing samples.
Journal ArticleDOI
Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging.
Gijs van Soest,Thadé P. M. Goderie,Evelyn Regar,Senada Koljenović,Geert L. J. H. van Leenders,Nieves Gonzalo,Sander van Noorden,Takayuki Okamura,Brett E. Bouma,Guillermo J. Tearney,J. Wolter Oosterhuis,Patrick W. Serruys,Anton F. W. van der Steen +12 more
TL;DR: This work presents a framework to enable systematic and automatic classification of atherosclerotic plaque constituents, based on the optical attenuation coefficient mu(t) of the tissue, and successfully applies the algorithm to OCT patient data.
Journal ArticleDOI
Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography
Seemantini K. Nadkarni,Mark C. Pierce,B. Hyle Park,Johannes F. de Boer,Peter Whittaker,Brett E. Bouma,Jason Bressner,Elkan F. Halpern,Stuart L. Houser,Guillermo J. Tearney +9 more
TL;DR: The results demonstrate that PSOCT enables the measurement of birefringence in plaques and in fibrous caps of necrotic core fibroatheromas and will significantly improve the ability to evaluate plaque stability in patients.
Journal ArticleDOI
Optical Biopsy in Human Urologic Tissue Using Optical Coherence Tomography
Guillermo J. Tearney,Mark E. Brezinski,James F. Southern,Brett E. Bouma,Stephen A. Boppart,James G. Fujimoto +5 more
TL;DR: The ability of OCT to provide non-contact high resolution imaging of urologic tissue architectural morphology (i.e. optical biopsy), without the need for excisional biopsy, suggests the potential of using OCT to obtain information on tissue microstructure that could only previously be obtained with conventional biopsy.