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Brian A. Morgan
Researcher at Newcastle University
Publications - 57
Citations - 6065
Brian A. Morgan is an academic researcher from Newcastle University. The author has contributed to research in topics: Schizosaccharomyces pombe & Thioredoxin. The author has an hindex of 36, co-authored 57 publications receiving 5669 citations. Previous affiliations of Brian A. Morgan include University of Newcastle & National Institute for Medical Research.
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Journal ArticleDOI
Hydrogen Peroxide Sensing and Signaling
TL;DR: The molecular mechanisms by which hydrogen peroxide is sensed and the increasing evidence that antioxidant enzymes play multiple, key roles as sensors and regulators of signal transduction in response to hydrogen peroxy are discussed.
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Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1
TL;DR: It is demonstrated that the cellular response to oxidative stress and to treatment with a variety of cytotoxic agents is the result of Sty1 regulation of the Pap1 transcription factor, a bZip protein with structural and DNA binding similarities to the mammalian c-Jun protein.
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The Skn7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae
Brian A. Morgan,Brian A. Morgan,Geoffrey R. Banks,W. Mark Toone,Desmond Raitt,Shusuke Kuge,Leland H. Johnston +6 more
TL;DR: It is demonstrated that following oxidative stress, Skn7 regulates the induction of two genes: TRX2, encoding thioredoxin, and a gene encoding thIoredoxin reductase, which is significantly regulated by Yap1.
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A Conserved Stress-activated Protein Kinase Regulates a Core Stress Response in the Human Pathogen Candida albicans
TL;DR: The Hog1 stress-activated protein kinase (SAPK) is phosphorylated and it accumulates in the nucleus in response to diverse stress conditions, and the core stress response in C. albicans has adapted to the environmental niche of this human pathogen.
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A 2-Cys Peroxiredoxin Regulates Peroxide-Induced Oxidation and Activation of a Stress-Activated MAP Kinase
Elizabeth A. Veal,Victoria J. Findlay,Alison M. Day,Stephanie M. Bozonet,Jennifer M. Evans,Janet Quinn,Brian A. Morgan +6 more
TL;DR: It is revealed that Tpx1, the single 2-Cys Prx in Schizosaccharomyces pombe, is required for the peroxide-induced activation of the p38/JNK homolog, Sty1, which provides new insight into the response of SAPKs to diverse stimuli by revealing a mechanism for SAPK activation specifically by oxidative stress.