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Brian B. Graham
Researcher at University of California, San Francisco
Publications - 115
Citations - 4376
Brian B. Graham is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Pulmonary hypertension & Lung. The author has an hindex of 34, co-authored 96 publications receiving 3558 citations. Previous affiliations of Brian B. Graham include San Francisco General Hospital & University of Colorado Denver.
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Journal ArticleDOI
Modern age pathology of pulmonary arterial hypertension.
Elvira Stacher,Brian B. Graham,James M. Hunt,Aneta Gandjeva,Steve D. Groshong,Vallerie V. McLaughlin,Marsha Jessup,William E. Grizzle,Michaela A. Aldred,Carlyne D. Cool,Rubin M. Tuder +10 more
TL;DR: The results indicate that multiple features of pulmonary vascular remodeling are present in patients treated with modern PAH therapies, and perivascular inflammation may have an important role in the processes ofascular remodeling, all of which may ultimately lead to increased pulmonary artery pressure.
Journal ArticleDOI
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension
Thomas Bertero,Yu Lu,Sofia Annis,Andrew E. Hale,Balkrishen Bhat,Rajan Saggar,Rajeev Saggar,W. Dean Wallace,David J. Ross,Sara O. Vargas,Brian B. Graham,Rajesh Kumar,Stephen M. Black,Sohrab Fratz,Jeffrey R. Fineman,James West,Kathleen J. Haley,Aaron B. Waxman,B. Nelson Chau,Katherine A. Cottrill,Stephen Y. Chan +20 more
TL;DR: Analysis of the molecular network architecture specific to PH predicted that the miR-130/301 family is a master regulator of cellular proliferation in PH via regulation of subordinate miRNA pathways with unexpected connections to one another.
Journal ArticleDOI
Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit
Thomas Bertero,Katherine A. Cottrill,Yu Lu,Christina Mallarino Haeger,Paul B. Dieffenbach,Sofia Annis,Andrew E. Hale,Balkrishen Bhat,Vivek Kaimal,Ying Yi Zhang,Brian B. Graham,Rajesh Kumar,Rajan Saggar,Rajeev Saggar,W. Dean Wallace,David J. Ross,Stephen M. Black,Sohrab Fratz,Jeffrey R. Fineman,Sara O. Vargas,Kathleen J. Haley,Aaron B. Waxman,B. Nelson Chau,Laura E. Fredenburgh,Stephen Y. Chan +24 more
TL;DR: ECM remodeling, as controlled by the YAP/TAZ-miR-130/301 feedback circuit, is an early PH trigger and offers combinatorial therapeutic targets for this devastating disease.
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Adventitial Fibroblasts Induce a Distinct Proinflammatory/Profibrotic Macrophage Phenotype in Pulmonary Hypertension
Karim C. El Kasmi,Steven C. Pugliese,Suzette R. Riddle,Jens M. Poth,Aimee L. Anderson,Maria G. Frid,Min Li,Soni Savai Pullamsetti,Rajkumar Savai,Maria A. Nagel,Mehdi A. Fini,Brian B. Graham,Rubin M. Tuder,Jacob E. Friedman,Holger K. Eltzschig,Ronald J. Sokol,Kurt R. Stenmark +16 more
TL;DR: These findings challenge the current paradigm of IL-4/IL-13–STAT6–mediated alternative macrophage activation as the sole driver of vascular remodeling in PH, and uncover a cross-talk between adventitial fibroblasts and macrophages in which paracrine IL-6–activated STAT3, HIF1α, and C/EBPβ signaling are critical for macrophAGE activation and polarization.
Journal ArticleDOI
Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α
Manik C. Ghosh,De-Liang Zhang,Suh Young Jeong,Gennadiy Kovtunovych,Hayden Ollivierre-Wilson,Audrey Noguchi,Tiffany Tu,Thomas Senecal,Gabrielle Robinson,Daniel R. Crooks,Wing Hang Tong,Kavitha Ramaswamy,Anamika Singh,Brian B. Graham,Rubin M. Tuder,Zu Xi Yu,Michael Eckhaus,Jaekwon Lee,Danielle A. Springer,Tracey A. Rouault +19 more
TL;DR: The results reveal why anemia is an early physiological consequence of iron deficiency, highlight the physiological significance of Irp1 in regulating erythropoiesis and iron distribution, and provide important insights into the molecular pathogenesis of pulmonary hypertension.