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Sofia Annis
Researcher at Northeastern University
Publications - 30
Citations - 1046
Sofia Annis is an academic researcher from Northeastern University. The author has contributed to research in topics: Mitochondrial DNA & Numt. The author has an hindex of 11, co-authored 24 publications receiving 858 citations. Previous affiliations of Sofia Annis include Harvard University & Brigham and Women's Hospital.
Papers
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Journal ArticleDOI
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension
Thomas Bertero,Yu Lu,Sofia Annis,Andrew E. Hale,Balkrishen Bhat,Rajan Saggar,Rajeev Saggar,W. Dean Wallace,David J. Ross,Sara O. Vargas,Brian B. Graham,Rajesh Kumar,Stephen M. Black,Sohrab Fratz,Jeffrey R. Fineman,James West,Kathleen J. Haley,Aaron B. Waxman,B. Nelson Chau,Katherine A. Cottrill,Stephen Y. Chan +20 more
TL;DR: Analysis of the molecular network architecture specific to PH predicted that the miR-130/301 family is a master regulator of cellular proliferation in PH via regulation of subordinate miRNA pathways with unexpected connections to one another.
Journal ArticleDOI
Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit
Thomas Bertero,Katherine A. Cottrill,Yu Lu,Christina Mallarino Haeger,Paul B. Dieffenbach,Sofia Annis,Andrew E. Hale,Balkrishen Bhat,Vivek Kaimal,Ying Yi Zhang,Brian B. Graham,Rajesh Kumar,Rajan Saggar,Rajeev Saggar,W. Dean Wallace,David J. Ross,Stephen M. Black,Sohrab Fratz,Jeffrey R. Fineman,Sara O. Vargas,Kathleen J. Haley,Aaron B. Waxman,B. Nelson Chau,Laura E. Fredenburgh,Stephen Y. Chan +24 more
TL;DR: ECM remodeling, as controlled by the YAP/TAZ-miR-130/301 feedback circuit, is an early PH trigger and offers combinatorial therapeutic targets for this devastating disease.
Journal ArticleDOI
Bone Morphogenetic Protein-2 Decreases MicroRNA-30b and MicroRNA-30c to Promote Vascular Smooth Muscle Cell Calcification
Joshua A Balderman,Hae-Young Lee,Christopher E Mahoney,Diane E. Handy,Kevin P. White,Sofia Annis,Djamel Lebeche,Roger J. Hajjar,Joseph Loscalzo,Jane A. Leopold +9 more
TL;DR: BMP‐2 downregulates miR‐30b and miC‐30c to increase Runx2 expression in CASMCs and promote mineralization and strategies that modulate expression of miR30band miR•30c may influence vascular calcification.
Journal ArticleDOI
Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension
Kevin P. White,Yu Lu,Sofia Annis,Andrew E. Hale,B. Nelson Chau,James E. Dahlman,Craig Hemann,Alexander R. Opotowsky,Sara O. Vargas,Ivan O. Rosas,Mark A. Perrella,Juan C. Osorio,Kathleen J. Haley,Brian B. Graham,Rajesh Kumar,Rajan Saggar,Rajeev Saggar,W. Dean Wallace,David J. Ross,Omar F. Khan,Andrew Bader,Bernadette R. Gochuico,Majed Matar,Kevin J. Polach,Nicolai M. Johannessen,Haydn M. Prosser,Daniel G. Anderson,Robert Langer,Jay L. Zweier,Laurence A. Bindoff,Laurence A. Bindoff,David M. Systrom,Aaron B. Waxman,Richard C Jin,Stephen Y. Chan +34 more
TL;DR: In this paper, the miR-210-ISCU1/2 regulatory axis was found to be a pathogenic lynchpin causing Fe-S deficiency and pulmonary hypertension.
Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension
Kevin P. White,Y. Lu,Sofia Annis,Andrew E. Hale,B. N. Chau,James E. Dahlman,Craig Hemann,Alexander R. Opotowsky,Sara O. Vargas,Ivan O. Rosas,Mark A. Perrella,Juan C. Osorio,Kathleen J. Haley,Brian B. Graham,Rajesh Kumar,Rajan Saggar,William D. Wallace,David J. Ross,Omar F. Khan,Andrew Bader,Bernadette R. Gochuico,Majed Matar,Kevin J. Polach,Nicolai M. Johannessen,Haydn M. Prosser,Daniel G. Anderson,Robert Langer,Jay L. Zweier,Laurence A. Bindoff,David M. Systrom,Aaron B. Waxman,R. C. Jin,Stephen Y. Chan +32 more
TL;DR: The miR‐210‐ISCU1/2 regulatory axis is a pathogenic lynchpin causing Fe‐S deficiency and PH, and these findings carry broad translational implications for defining the metabolic origins of PH and potentially other metabolic diseases sharing similar underpinnings.