S
Sébastien S. Hébert
Researcher at Laval University
Publications - 81
Citations - 7192
Sébastien S. Hébert is an academic researcher from Laval University. The author has contributed to research in topics: Amyloid precursor protein & microRNA. The author has an hindex of 38, co-authored 78 publications receiving 6286 citations. Previous affiliations of Sébastien S. Hébert include Huazhong University of Science and Technology & Flanders Institute for Biotechnology.
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Journal ArticleDOI
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.
Sébastien S. Hébert,Katrien Horré,Laura Nicolaï,Aikaterini S. Papadopoulou,Wim Mandemakers,Asli Silahtaroglu,Sakari Kauppinen,Sakari Kauppinen,André Delacourte,Bart De Strooper +9 more
TL;DR: It is shown here that miR-29a, -29b-1, and -9 can regulate Bace1 expression in vitro and proposed that loss of specific miRNAs can contribute to increased BACE1 and Aβ levels in sporadic AD.
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Alterations of the microRNA network cause neurodegenerative disease.
TL;DR: Evidence from patient material is emerging that miRNA dysregulation could, indeed, contribute to neurodegenerative disorders, and miRNAs are moving rapidly center stage as key regulators of neuronal development and function in addition to important contributors to neuro degenerative disorder.
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Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis
Tracy O'Connor,Katherine R. Sadleir,Erika Maus,Rodney A. Velliquette,Jie Zhao,Sarah L. Cole,William A. Eimer,Brian Hitt,Leslie A. Bembinster,Sven Lammich,Stefan F. Lichtenthaler,Sébastien S. Hébert,Bart De Strooper,Christian Haass,David A. Bennett,Robert Vassar +15 more
TL;DR: It is strongly suggested that eIF2alpha phosphorylation increases BACE1 levels and causes Abeta overproduction, which could be an early, initiating molecular mechanism in sporadic AD.
Journal ArticleDOI
MicroRNA regulation of Alzheimer's Amyloid precursor protein expression
Sébastien S. Hébert,Katrien Horré,Laura Nicolaï,Bruno Bergmans,Aikaterini S. Papadopoulou,André Delacourte,Bart De Strooper +6 more
TL;DR: It is shown that miRNAs belonging to the miR-20a family could regulate APP expression in vitro and at the endogenous level in neuronal cell lines, suggesting that variations in miRNA expression could contribute to changes inAPP expression in the brain during development and disease.
Journal ArticleDOI
The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases.
John R. Finnerty,John R. Finnerty,Wang-Xia Wang,Wang-Xia Wang,Sébastien S. Hébert,Sébastien S. Hébert,Bernard R. Wilfred,Bernard R. Wilfred,Guogen Mao,Guogen Mao,Peter T. Nelson,Peter T. Nelson +11 more
TL;DR: The miR-15/107 group of microRNA genes is a fascinating topic of study for evolutionary biologists, miRNA biochemists, and clinically oriented translational researchers alike and the roles played by these miRNAs in human diseases are investigated.