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Brian R. Crane
Researcher at Cornell University
Publications - 183
Citations - 11342
Brian R. Crane is an academic researcher from Cornell University. The author has contributed to research in topics: Histidine kinase & Heme. The author has an hindex of 58, co-authored 171 publications receiving 10403 citations. Previous affiliations of Brian R. Crane include Albert Einstein College of Medicine & Cleveland Clinic.
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Journal ArticleDOI
Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.
Brian R. Crane,Brian R. Crane,Andrew S. Arvai,Dipak K. Ghosh,Chaoqun Wu,Elizabeth D. Getzoff,Dennis J. Stuehr,John A. Tainer +7 more
TL;DR: Crystal structures of the murine cytokine-inducible nitric oxide synthase oxygenase dimer with active-center water molecules, the substrate L-arginine (L-Arg), or product analog thiocitrulline reveal how dimerization, cofactor tetrahydrobiopterin, and L-Arg binding complete the catalytic center for synthesis of the essential biological signal and cytotoxin nitricoxide.
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Structure of CheA, a Signal-Transducing Histidine Kinase
TL;DR: A resolution crystal structure of Thermotoga maritima CheA reveals a dimer where the functions of dimerization, ATP binding, and regulation are segregated into domains, suggesting that relative domain motions link receptor response to kinase activity.
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Tryptophan-Accelerated Electron Flow Through Proteins
Crystal Shih,Anna Katrine Museth,Malin Abrahamsson,Ana María Blanco-Rodríguez,Angel J. Di Bilio,Jawahar Sudhamsu,Brian R. Crane,Kate L. Ronayne,Michael Towrie,Antonín Vlček,John H. Richards,Jay R. Winkler,Harry B. Gray +12 more
TL;DR: In this paper, transient optical and infrared spectroscopic experiments were conducted to quantify the extent to which an intervening tryptophan residue can facilitate electron transfer between distant metal redox centers in a mutant Pseudomonas aeruginosa azurin.
Journal ArticleDOI
The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.
Brian R. Crane,Andrew S. Arvai,Ratan Gachhui,Chaoqun Wu,Dipak K. Ghosh,Elizabeth D. Getzoff,Dennis J. Stuehr,John A. Tainer +7 more
TL;DR: Juxtaposed hydrophobic O2- and polar L-arginine-binding sites occupied by imidazole and aminoguanidine, respectively, provide a template for designing dual-function inhibitors and imply substrate-assisted catalysis.
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Conformational switching in the fungal light sensor Vivid.
Brian D. Zoltowski,Carsten Schwerdtfeger,Carsten Schwerdtfeger,Joanne Widom,Joanne Widom,Jennifer J. Loros,Jennifer J. Loros,Alexandrine M. Bilwes,Alexandrine M. Bilwes,Jay C. Dunlap,Jay C. Dunlap,Brian R. Crane,Brian R. Crane +12 more
TL;DR: The Neurospora crassa photoreceptor Vivid tunes blue-light responses and modulates gating of the circadian clock and key elements of this activation mechanism are conserved by other photosensors such as White Collar-1, ZEITLUPE, ENVOY, and flavin-binding, kelch repeat, F-BOX 1.