R
Ratan Gachhui
Researcher at Jadavpur University
Publications - 70
Citations - 2930
Ratan Gachhui is an academic researcher from Jadavpur University. The author has contributed to research in topics: Chemistry & Oxidative stress. The author has an hindex of 24, co-authored 60 publications receiving 2543 citations. Previous affiliations of Ratan Gachhui include Cleveland Clinic Lerner Research Institute & University of Calcutta.
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Journal ArticleDOI
The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.
Brian R. Crane,Andrew S. Arvai,Ratan Gachhui,Chaoqun Wu,Dipak K. Ghosh,Elizabeth D. Getzoff,Dennis J. Stuehr,John A. Tainer +7 more
TL;DR: Juxtaposed hydrophobic O2- and polar L-arginine-binding sites occupied by imidazole and aminoguanidine, respectively, provide a template for designing dual-function inhibitors and imply substrate-assisted catalysis.
Journal ArticleDOI
Structural Basis for Isozyme-specific Regulation of Electron Transfer in Nitric-oxide Synthase
Elsa D. Garcin,Christopher M. Bruns,S.J. Lloyd,David J. Hosfield,Mauro Tiso,Ratan Gachhui,Ratan Gachhui,Dennis J. Stuehr,John A. Tainer,Elizabeth D. Getzoff +9 more
TL;DR: This work addresses current questions regarding NOS activity and regulation by combining mutagenesis and biochemistry with crystal structure determination of a fully assembled, electron-supplying, neuronal NOS reductase dimer and structurally elucidate the unique mechanisms for isozyme-specific regulation of electron transfer in NOS.
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Kombucha tea fermentation: Microbial and biochemical dynamics.
Somnath Chakravorty,Semantee Bhattacharya,Antonis Chatzinotas,Writachit Chakraborty,Debanjana Bhattacharya,Ratan Gachhui +5 more
TL;DR: The data indicate that the microbial community structure and dynamics play an important role in the biochemistry of the fermentation of the beverage and a significantly higher D-saccharic acid-1,4-lactone content and caffeine degradation property compared to previously described Kombucha tea fermentations.
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Interaction between Caveolin-1 and the Reductase Domain of Endothelial Nitric-oxide Synthase CONSEQUENCES FOR CATALYSIS
TL;DR: It is proposed that cav-1 binding to eNOS reductase compromises its ability to bind CaM and to donate electrons to the eN OS heme, thereby inhibiting NO synthesis.
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The Ferrous-dioxy Complex of Neuronal Nitric Oxide Synthase: DIVERGENT EFFECTS OF l-ARGININE AND TETRAHYDROBIOPTERIN ON ITS STABILITY
TL;DR: The spectral and kinetic properties of the intermediate identify it as the FeIIO2 complex of nNOSoxy, which may be important regarding the role of this cofactor in NO synthesis.