B
Brian T. DeVree
Researcher at University of Michigan
Publications - 21
Citations - 6544
Brian T. DeVree is an academic researcher from University of Michigan. The author has contributed to research in topics: G protein-coupled receptor & G protein. The author has an hindex of 13, co-authored 20 publications receiving 5893 citations. Previous affiliations of Brian T. DeVree include University of Copenhagen.
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Journal ArticleDOI
Crystal structure of the β2 adrenergic receptor-Gs protein complex.
Søren G. F. Rasmussen,Brian T. DeVree,Yaozhong Zou,Andrew C. Kruse,Ka Young Chung,Tong Sun Kobilka,Foon Sun Thian,Pil Seok Chae,Els Pardon,Els Pardon,Diane M. Calinski,Jesper Mosolff Mathiesen,Syed T. A. Shah,Joseph A. Lyons,Martin Caffrey,Samuel H. Gellman,Jan Steyaert,Jan Steyaert,Georgios Skiniotis,William I. Weis,Roger K. Sunahara,Brian K. Kobilka +21 more
TL;DR: This crystal structure represents the first high-resolution view of transmembrane signalling by a GPCR and the most surprising observation is a major displacement of the α-helical domain of Gαs relative to the Ras-like GTPase domain.
Journal ArticleDOI
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
Søren G. F. Rasmussen,Hee Jung Choi,Juan Jose Fung,Els Pardon,Paola Casarosa,Pil Seok Chae,Brian T. DeVree,Daniel M. Rosenbaum,Foon Sun Thian,Tong Sun Kobilka,Andreas Schnapp,Ingo Konetzki,Roger K. Sunahara,Samuel H. Gellman,Alexander Pautsch,Jan Steyaert,William I. Weis,Brian K. Kobilka +17 more
TL;DR: A camelid antibody fragment to the human β2 adrenergic receptor is generated, and an agonist-bound, active-state crystal structure of the receptor-nanobody complex is obtained, providing insights into the process of agonist binding and activation.
Journal ArticleDOI
Structure and function of an irreversible agonist-β2 adrenoceptor complex
Daniel M. Rosenbaum,Cheng Zhang,Joseph A. Lyons,Joseph A. Lyons,Ralph Holl,David Aragão,Daniel H. Arlow,Sã̧ren G F Rasmussen,Hee Jung Choi,Brian T. DeVree,Roger K. Sunahara,Pil Seok Chae,Samuel H. Gellman,Ron O. Dror,David E. Shaw,William I. Weis,Martin Caffrey,Peter Gmeiner,Brian K. Kobilka +18 more
TL;DR: A covalent agonist-bound β2AR–T4L fusion protein is designed that can be covalently tethered to a specific site on the receptor through a disulphide bond, and is capable of activating a heterotrimeric G protein.
Journal ArticleDOI
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor.
Ka Young Chung,Søren G. F. Rasmussen,Søren G. F. Rasmussen,Tong Liu,Sheng Li,Brian T. DeVree,Pil Seok Chae,Pil Seok Chae,Diane M. Calinski,Brian K. Kobilka,Virgil L. Woods,Roger K. Sunahara +11 more
TL;DR: Structural links between the receptor-binding surface and the nucleotide-binding pocket of Gs that undergo higher levels of hydrogen–deuterium exchange than would be predicted from the crystal structure of the β2AR–Gs complex are reported.
Journal ArticleDOI
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex.
Xiao Jie Yao,Gisselle Vélez Ruiz,Matthew R. Whorton,Søren G. F. Rasmussen,Brian T. DeVree,Xavier Deupi,Roger K. Sunahara,Brian K. Kobilka +7 more
TL;DR: Insight is provided into G protein-induced conformational changes in the β2AR and the structural basis for ligand efficacy and the molecular mechanism for basal activation and inhibition of basal activity by inverse agonists is poorly understood.