Syed T. A. Shah

TL;DR: This crystal structure represents the first high-resolution view of transmembrane signalling by a GPCR and the most surprising observation is a major displacement of the α-helical domain of Gαs relative to the Ras-like GTPase domain.

TL;DR: This work presents a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond crystallography.

TL;DR: The structure of a human serotonin receptor was solved using a free-electron laser to analyze microcrystals and displays a distinct distribution of thermal motions and conformations of residues that likely more accurately represent the receptor structure and dynamics in a cellular environment.

TL;DR: Crystal structures of di‐ and tripeptide‐bound complexes of a bacterial homologue of PepT1 reveal at least two mechanisms for peptide recognition that operate within a single, centrally located binding site, and suggest that transport promiscuity has arisen in part through the ability of the binding site to accommodate peptides in multiple orientations for transport.

TL;DR: Crystal structures for three functional forms of diacylglycerol kinase reveal a homo-trimeric enzyme with three transmembrane helices and an amino-terminal amphiphilic helix per monomer, one of which is wild type.