S
Sheng Li
Researcher at University of California, San Diego
Publications - 150
Citations - 6202
Sheng Li is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Hydrogen–deuterium exchange & Epitope. The author has an hindex of 43, co-authored 138 publications receiving 5269 citations. Previous affiliations of Sheng Li include University of Texas Southwestern Medical Center & Laboratory of Molecular Biology.
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Journal ArticleDOI
Visualization of arrestin recruitment by a G-protein-coupled receptor
Arun K. Shukla,Gerwin Westfield,Kunhong Xiao,Rosana I. Reis,Li-Yin Huang,Prachi Tripathi-Shukla,Jiang Qian,Sheng Li,Adi Blanc,Austin N. Oleskie,Anne M. Dosey,Min Su,Cui Rong Liang,Ling Ling Gu,Jin Ming Shan,Xin Chen,Rachel Hanna,Minjung Choi,Xiao Jie Yao,Bjoern U. Klink,Alem W. Kahsai,Sachdev S. Sidhu,Shohei Koide,Pawel A. Penczek,Anthony A. Kossiakoff,Virgil L. Woods,Brian K. Kobilka,Georgios Skiniotis,Robert J. Lefkowitz +28 more
TL;DR: A strategy for forming and purifying a functional human β2AR–β-arrestin-1 complex is devised that provides a framework for better understanding the basis of GPCR regulation by arrestins.
Journal ArticleDOI
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor.
Ka Young Chung,Søren G. F. Rasmussen,Søren G. F. Rasmussen,Tong Liu,Sheng Li,Brian T. DeVree,Pil Seok Chae,Pil Seok Chae,Diane M. Calinski,Brian K. Kobilka,Virgil L. Woods,Roger K. Sunahara +11 more
TL;DR: Structural links between the receptor-binding surface and the nucleotide-binding pocket of Gs that undergo higher levels of hydrogen–deuterium exchange than would be predicted from the crystal structure of the β2AR–Gs complex are reported.
Journal ArticleDOI
Structural flexibility of the Gαs α-helical domain in the β 2-adrenoceptor Gs complex
Gerwin Westfield,Søren G. F. Rasmussen,Søren G. F. Rasmussen,Min Su,Somnath Dutta,Brian T. DeVree,Ka Young Chung,Diane Calinski,Gisselle A. Vélez-Ruiz,Austin N. Oleskie,Els Pardon,Pil Seok Chae,Tong Liu,Sheng Li,Virgil L. Woods,Jan Steyaert,Brian Kobilka,Roger K. Sunahara,Georgios Skiniotis +18 more
TL;DR: Molecular modeling of the α-helical domain in the 3D EM maps suggests that in its stabilized form it assumes a conformation reminiscent to the one observed in the crystal structure of Gαs-GTPγS.
Journal ArticleDOI
A protein fold switch joins the circadian oscillator to clock output in cyanobacteria
Yong-Gang Chang,Susan E. Cohen,Connie Phong,William K. Myers,Yong Ick Kim,Roger Tseng,Jenny J. Lin,Li Zhang,Joseph S. Boyd,Yvonne M Lee,Shannon Kang,David Lee,Sheng Li,R. David Britt,Michael J. Rust,Susan S. Golden,Andy LiWang +16 more
TL;DR: It is shown that KaiB flips between two distinct three-dimensional folds, and its rare transition to an active state provides a time delay that is required to match the timing of the oscillator to that of Earth’s rotation.
Journal ArticleDOI
A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface
Sandhya Bangaru,Shanshan Lang,Michael Schotsaert,Hillary A. Vanderven,Xueyong Zhu,Nurgun Kose,Robin G. Bombardi,Jessica A. Finn,Stephen J. Kent,Pavlo Gilchuk,Iuliia M. Gilchuk,Hannah L. Turner,Adolfo García-Sastre,Sheng Li,Andrew B. Ward,Ian A. Wilson,James E. Crowe +16 more
TL;DR: The discovery of a naturally occurring human antibody, FluA-20, that recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts with most influenza A viruses is described.