A
Arsène Ratsimbasoa
Researcher at University of Antananarivo
Publications - 66
Citations - 1992
Arsène Ratsimbasoa is an academic researcher from University of Antananarivo. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 21, co-authored 58 publications receiving 1767 citations. Previous affiliations of Arsène Ratsimbasoa include Pasteur Institute.
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Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy people
Didier Menard,Céline Barnadas,Christiane Bouchier,Cara N. Henry-Halldin,Laurie R. Gray,Arsène Ratsimbasoa,Vincent Thonier,Jean François Carod,Olivier Domarle,Yves Colin,Olivier F. Bertrand,Julien Picot,Christopher L. King,Brian T. Grimberg,Odile Mercereau-Puijalon,Peter A. Zimmerman +15 more
TL;DR: Findings established a paradigm that P. vivax has broken through its dependence on the Duffy antigen for establishing human blood-stage infection and disease in association with Duffy blood group polymorphism in Madagascar.
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Plasmodium vivax Resistance to Chloroquine in Madagascar: Clinical Efficacy and Polymorphisms in pvmdr1 and pvcrt-o Genes
Céline Barnadas,Arsène Ratsimbasoa,Magali Tichit,Christiane Bouchier,Martial Jahevitra,Stéphane Picot,Didier Menard +6 more
TL;DR: The findings suggest that CQ-resistant P. vivax isolates are present in Madagascar, particularly in the foothills of the Central Highlands, and further efforts are required to develop suitable tools for monitoring drug resistance.
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Whole genome sequencing of field isolates reveals a common duplication of the Duffy binding protein gene in Malagasy Plasmodium vivax strains.
Didier Menard,Ernest R. Chan,Christophe Benedet,Arsène Ratsimbasoa,Saorin Kim,Pheaktra Chim,Catherine Do,Benoit Witkowski,Rémy Durand,Marc Thellier,Carlo Severini,Eric Legrand,Lise Musset,Bakri Y. M. Nour,Odile Mercereau-Puijalon,David Serre,Peter A. Zimmerman +16 more
TL;DR: The discovery of a duplication of the P. vivax Duffy binding protein (PvDBP) gene suggests that PvDBP, a merozoite surface protein involved in red cell adhesion is rapidly evolving, possibly in response to constraints imposed by erythrocyte Duffy negativity in some human populations.
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Randomized, multicentre assessment of the efficacy and safety of ASAQ – a fixed-dose artesunate-amodiaquine combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria
Jean Louis Ndiaye,Milijaona Randrianarivelojosia,Issaka Sagara,Philippe Brasseur,Ibrahima Ndiaye,Babacar Faye,Laurence Randrianasolo,Arsène Ratsimbasoa,Doris Forlemu,Vicky Jocelyne Ama Moor,Aminata Traore,Yahia Dicko,Niawanlou Dara,Valerie Lameyre,Mouctar Diallo,Abdoulaye Djimde,Albert Same-Ekobo,Oumar Gaye +17 more
TL;DR: The non-inferiority of ASAQ compared with AL was demonstrated and the fixed-dose combination artesunate + amodiaquine (ASAQ) is safe and efficacious even in young children under 5 years of age.
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Plasmodium vivax diversity and population structure across four continents
Cristian Koepfli,Priscila T. Rodrigues,Tiago Antao,Pamela Orjuela-Sánchez,Peter Van den Eede,Dionicia Gamboa,Nguyen Van Hong,Jorge Bendezu,Annette Erhart,Céline Barnadas,Arsène Ratsimbasoa,Didier Menard,Carlo Severini,Michela Menegon,Bakri Y. M. Nour,Nadira D. Karunaweera,Ivo Mueller,Marcelo U. Ferreira,Ingrid Felger +18 more
TL;DR: Comparisons between P. vivax populations from four continents indicated that not only transmission intensity, but also geographical isolation affect diversity and population structure, however, the high effective population size results in slow changes of these parameters.