J
Jozef Laureys
Researcher at Katholieke Universiteit Leuven
Publications - 26
Citations - 2272
Jozef Laureys is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: NOD mice & Immune system. The author has an hindex of 17, co-authored 26 publications receiving 2206 citations. Previous affiliations of Jozef Laureys include Catholic University of Leuven.
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Journal ArticleDOI
Prevention of autoimmune diabetes in NOD mice by 1,25 dihydroxyvitamin D3
TL;DR: It is reported that treatment with 1,25 dihydroxyvitamin D3 (5 μg/kg on alternate days) prevents the development of clinical diabetes in NOD mice, an animal model of human autoimmune diabetes.
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Identification and immune regulation of 25-hydroxyvitamin D-1-alpha-hydroxylase in murine macrophages.
Lutgart Overbergh,Brigitte Decallonne,Dirk Valckx,Annemieke Verstuyf,Jos Depovere,Jozef Laureys,Omer Rutgeerts,Rene Saint-Arnaud,Roger Bouillon,Chantal Mathieu +9 more
TL;DR: It is proposed that the up‐regulation of 1‐α‐hydroxylase in activated macrophages, resulting in the synthesis of 1,25(OH)2D3, might be a negative feedback loop in inflammation.
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Influence of age, sex, and insulin on osteoblast function : Osteoblast dysfunction in diabetes mellitus.
TL;DR: The osteoblast function is significantly decreased in diabetic patients, which can best be characterized as a maturation defect, since the early osteooblast marker, PICP, remained normal in all types of diabetes, whereas a later marker, skeletal ALP, is frankly abnormal only in diabetic children.
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C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in umbilical cord serum: Correlations with birth weight
Johan Verhaeghe,Rita van Bree,Erik Van Herck,Jozef Laureys,Roger Bouillon,F. André Van Assche +5 more
TL;DR: Insulin, insulin- like growth factors I and II and insulin are all related to fetal growth and weight gain, and insulin-like growth factor-I correlates best with birth weight.
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1alpha,25-dihydroxyvitamin D3 induces an autoantigen-specific T-helper 1/T-helper 2 immune shift in NOD mice immunized with GAD65 (p524-543).
Lutgart Overbergh,Brigitte Decallonne,Mark Waer,Omer Rutgeerts,Dirk Valckx,Kristina Casteels,Jozef Laureys,Roger Bouillon,Chantal Mathieu +8 more
TL;DR: The immune deviation induced by 1alpha,25(OH)2D3 in NOD mice can also be induced in the peripheral immune system but is limited to pancreatic autoantigens.