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Damien Picard
Researcher at French Institute of Health and Medical Research
Publications - 13
Citations - 952
Damien Picard is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Eosinophilia & Odds ratio. The author has an hindex of 10, co-authored 13 publications receiving 830 citations.
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Journal ArticleDOI
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Multiorgan Antiviral T Cell Response
Damien Picard,Baptiste Janela,Vincent Descamps,Michel D'Incan,Philippe Courville,Serge Jacquot,Sylvie Rogez,Laurent Mardivirin,Hélène Moins-Teisserenc,Antoine Toubert,Jacques Benichou,Pascal Joly,Philippe Musette +12 more
TL;DR: The authors propose that DRESS is caused by an EBV (or other similar virus)–driven selection of CD8+ T lymphocytes, which in turn inappropriately attack multiple organs, and think that the culprit drugs may trigger activation of the patients’ dormant EBV by an as yet undefined mechanism, possibly directly.
Journal ArticleDOI
Long-Term Remissions of Severe Pemphigus After Rituximab Therapy Are Associated with Prolonged Failure of Desmoglein B Cell Response
Natacha Colliou,Damien Picard,Frédérique Caillot,Sébastien Calbo,Stéphanie Le Corre,Annick Lim,Brigitte Lemercier,Brigitte Le Mauff,Maud Maho-Vaillant,Serge Jacquot,Christophe Bedane,Philippe Bernard,Frédéric Caux,Catherine Prost,Emmanuel Delaporte,Marie-Sylvie Doutre,Brigitte Dréno,Nathalie Franck,Saskia Ingen-Housz-Oro,Olivier Chosidow,Christine Pauwels,Catherine Picard,Jean-Claude Roujeau,M.-L. Sigal,E. Tancrede-Bohin,Isabelle Templier,Rüdiger Eming,Michael Hertl,Michel D'Incan,Pascal Joly,Philippe Musette +30 more
TL;DR: It is found that rituximab therapy can help pemphigus patients even after 6 years, in part by reshaping the B cell repertoire during reconstitution, allowing for long-term effects in addition to the short-term loss of pathogenic B cells.
Journal ArticleDOI
Prognostic factors of paraneoplastic pemphigus.
Sandy Léger,Damien Picard,Saskia Ingen-Housz-Oro,Jean-Philippe Arnault,François Aubin,Francis Carsuzaa,Gilles Chaumentin,Jacqueline Chevrant-Breton,Olivier Chosidow,Béatrice Crickx,Michel D'Incan,M. Dandurand,Stéphane Debarbieux,Emmanuel Delaporte,Olivier Dereure,Marie-Sylvie Doutre,Gérard Guillet,Denis Jullien,I. Kupfer,Jean-Philippe Lacour,Fabienne Léonard,Catherine Lok,Laurent Machet,Ludovic Martin,Carle Paul,Jean-Michel Pignon,Caroline Robert,Luc Thomas,Pierre-Jean Weiller,Vincent Ferranti,Danièle Gilbert,Philippe Courville,Estelle Houivet,Jacques Benichou,Pascal Joly +34 more
TL;DR: Patients with PNP with erythema multiforme–like skin lesions and histologic keratinocyte necrosis, especially when associated with extensive lesions at presentation, are likely to have a more severe and rapid fatal outcome and should be managed very carefully.
Journal ArticleDOI
Poor Benefit/Risk Balance of Intravenous Immunoglobulins in DRESS
Pascal Joly,Baptiste Janela,Florence Tetart,Sylvie Rogez,Damien Picard,Michel D'Incan,Vincent Descamps,Evelyne Collet,Jean-Claude Roujeau,Philippe Musette +9 more
TL;DR: The aim of the present study was to evaluate the safety and efficacy of IVIGs in patients with DRESS and to assess the evolution of immunologic and virologic parameters after treatment.
Journal ArticleDOI
Drug Reaction with Eosinophilia and Systemic Symptoms: an update on pathogenesis
TL;DR: The present review discusses the latest findings concerning the pathogenesis of drug reactions and known risk factors for DRESS and describes the recent demonstration of Epstein-Barr virus-specific immune responses in DRESS patients.