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Brooke J. Bevis
Researcher at Massachusetts Institute of Technology
Publications - 6
Citations - 984
Brooke J. Bevis is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Endocytic cycle & Fungal prion. The author has an hindex of 3, co-authored 6 publications receiving 890 citations.
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Journal ArticleDOI
The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis
Aaron D. Gitler,Brooke J. Bevis,James Shorter,Katherine E. Strathearn,Shusei Hamamichi,Linhui Julie Su,Kim A. Caldwell,Guy A. Caldwell,Jean-Christophe Rochet,J. Michael McCaffery,Charles Barlowe,Susan Lindquist +11 more
TL;DR: Yeast α-syn inhibits endoplasmic reticulum-to-Golgi vesicle trafficking, which is rescued by overexpression of a Rab GTPase that regulates ER→golgi trafficking, and the homologous Rab1 rescues α- syn toxicity in dopaminergic neuronal models of PD.
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Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast
Sebastian Treusch,Shusei Hamamichi,Shusei Hamamichi,Jessica L. Goodman,Kent E. S. Matlack,Chee Yeun Chung,Valeriya Baru,Joshua M. Shulman,Joshua M. Shulman,Antonio R. Parrado,Brooke J. Bevis,Julie S. Valastyan,Haesun Han,Malin Lindhagen-Persson,Eric M. Reiman,Eric M. Reiman,Denis A. Evans,David A. Bennett,Anders Olofsson,Philip L. DeJager,Philip L. DeJager,Rudolph E. Tanzi,Kim A. Caldwell,Guy A. Caldwell,Susan Lindquist +24 more
TL;DR: In this article, the authors showed that β-amyloid peptide is an important contributor to Alzheimer's disease (AD) by directing the peptide to the secretory pathway.
Journal ArticleDOI
Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation
Jens Tyedmers,Sebastian Treusch,Jijun Dong,J. Michael McCaffery,Brooke J. Bevis,Susan Lindquist +5 more
TL;DR: In this article, a visually tractable prion model consisting of the Sup35 prion domain fused to GFP (PrD-GFP) and overexpressed it to achieve induction in many cells simultaneously was presented.
Journal Article
Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast
Joshua M. Shulman,Antonio R. Parrado,Malin Lindhagen-Persson,Eric M. Reiman,Denis A. Evans,David A. Bennett,Anders Olofsson,Philip L. De Jager,Rudolph E. Tanzi,Kim A. Caldwell,Guy A. Caldwell,Susan Lindquist,Sebastian Treusch,Shusei Hamamichi,Jessica L. Goodman,Kent E. S. Matlack,Chee Yeun Chung,Valeriya Baru,Julie S. Valastyan,Haesun Han,Brooke J. Bevis +20 more
TL;DR: In yeast, links between Aβ, endocytosis, and human AD risk factors can be ascertained with yeast as a model system by directing the peptide to the secretory pathway.
Journal ArticleDOI
Susan Lindquist: Visionary scientist and peerless mentor
TL;DR: As Sue's laboratory manager, I would like to offer a ground-floor perspective on what made her an exceptional scientist, mentor, and leader.