S
Shusei Hamamichi
Researcher at University of Alabama
Publications - 22
Citations - 2877
Shusei Hamamichi is an academic researcher from University of Alabama. The author has contributed to research in topics: RNA interference & Neurodegeneration. The author has an hindex of 14, co-authored 16 publications receiving 2606 citations. Previous affiliations of Shusei Hamamichi include Massachusetts Institute of Technology.
Papers
More filters
Journal ArticleDOI
Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity.
Aaron D. Gitler,Alessandra Chesi,Melissa Geddie,Katherine E. Strathearn,Shusei Hamamichi,Kathryn J. Hill,Kim A. Caldwell,Guy A. Caldwell,Antony A. Cooper,Jean-Christophe Rochet,Susan Lindquist +10 more
TL;DR: Dopaminergic neuron loss caused by α-syn overexpression in animal and neuronal PD models is rescued by coexpression of PARK9, and yeast PARK9 helps to protect cells from manganese toxicity, revealing a connection between PD genetics and an environmental risk factor.
Journal ArticleDOI
The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis
Aaron D. Gitler,Brooke J. Bevis,James Shorter,Katherine E. Strathearn,Shusei Hamamichi,Linhui Julie Su,Kim A. Caldwell,Guy A. Caldwell,Jean-Christophe Rochet,J. Michael McCaffery,Charles Barlowe,Susan Lindquist +11 more
TL;DR: Yeast α-syn inhibits endoplasmic reticulum-to-Golgi vesicle trafficking, which is rescued by overexpression of a Rab GTPase that regulates ER→golgi trafficking, and the homologous Rab1 rescues α- syn toxicity in dopaminergic neuronal models of PD.
Journal ArticleDOI
Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast
Sebastian Treusch,Shusei Hamamichi,Shusei Hamamichi,Jessica L. Goodman,Kent E. S. Matlack,Chee Yeun Chung,Valeriya Baru,Joshua M. Shulman,Joshua M. Shulman,Antonio R. Parrado,Brooke J. Bevis,Julie S. Valastyan,Haesun Han,Malin Lindhagen-Persson,Eric M. Reiman,Eric M. Reiman,Denis A. Evans,David A. Bennett,Anders Olofsson,Philip L. DeJager,Philip L. DeJager,Rudolph E. Tanzi,Kim A. Caldwell,Guy A. Caldwell,Susan Lindquist +24 more
TL;DR: In this article, the authors showed that β-amyloid peptide is an important contributor to Alzheimer's disease (AD) by directing the peptide to the secretory pathway.
Journal ArticleDOI
Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model.
TL;DR: Five previously unreported gene products are revealed that significantly protect against age- and dose-dependent α-syn-induced degeneration in the dopamine neurons of transgenic worms, and one gene reported to cause neurodegeneration in knockout mice.
Journal ArticleDOI
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
Liyan Qiao,Shusei Hamamichi,Kim A. Caldwell,Guy A. Caldwell,Talene A. Yacoubian,Scott M. Wilson,Zuo-Lei Xie,Lisa D Speake,Rachael Parks,Donna M. Crabtree,Qiuli Liang,Stephen L. Crimmins,Lonnie Schneider,Yasuo Uchiyama,Takeshi Iwatsubo,Yi Zhou,Lisheng Peng,YouMing Lu,David G. Standaert,Ken C. Walls,John J. Shacka,John J. Shacka,Kevin A. Roth,Jianhua Zhang +23 more
TL;DR: The data identify a conserved CD function in α-syn degradation and identify CD as a novel target for LB disease therapeutics.