P
Philip L. DeJager
Researcher at Brigham and Women's Hospital
Publications - 4
Citations - 588
Philip L. DeJager is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Genome-wide association study & P3 peptide. The author has an hindex of 4, co-authored 4 publications receiving 525 citations. Previous affiliations of Philip L. DeJager include Broad Institute.
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Journal ArticleDOI
Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast
Sebastian Treusch,Shusei Hamamichi,Shusei Hamamichi,Jessica L. Goodman,Kent E. S. Matlack,Chee Yeun Chung,Valeriya Baru,Joshua M. Shulman,Joshua M. Shulman,Antonio R. Parrado,Brooke J. Bevis,Julie S. Valastyan,Haesun Han,Malin Lindhagen-Persson,Eric M. Reiman,Eric M. Reiman,Denis A. Evans,David A. Bennett,Anders Olofsson,Philip L. DeJager,Philip L. DeJager,Rudolph E. Tanzi,Kim A. Caldwell,Guy A. Caldwell,Susan Lindquist +24 more
TL;DR: In this article, the authors showed that β-amyloid peptide is an important contributor to Alzheimer's disease (AD) by directing the peptide to the secretory pathway.
GWAS for executive function and processing speed suggests involvement of the CADM2 gene
Carla A. Ibrahim-Verbaas,Jan Bressler,Stéphanie Debette,Maaike Schuur,Albert V. Smith,J. C. Bis,G. Davies,S. Trompet,Jennifer A. Smith,Christiane Wolf,Lori B. Chibnik,Yongmei Liu,Veronique Vitart,Mirna Kirin,K. Petrovic,Ozren Polasek,Lina Zgaga,Chloe Fawns-Ritchie,Peter Hoffmann,Juha Karjalainen,Jari Lahti,David J. Llewellyn,Christian Schmidt,Karen A. Mather,Vincent Chouraki,Qi Sun,Susan M. Resnick,Ludger Rose,Christopher Oldmeadow,Marlene C. W. Stewart,Blair H. Smith,Vilmundur Gudnason,Qiong Yang,Saira Saeed Mirza,Joop Jukema,Philip L. DeJager,T.B. Harris,D C Liewald,Najaf Amin,Laura H. Coker,Oliver Stegle,Oscar L. Lopez,R. Schmidt,A. Teumer,Ian Ford,Nazanin Karbalai,James T. Becker,Maria K. Jonsdottir,Rhoda Au,Rudolf S N Fehrmann,Stefan Herms,Michael A. Nalls,Wei Zhao,Stephen T. Turner,Kristine Yaffe,Kurt Lohman,J. C. van Swieten,Sharon L.R. Kardia,D. S. Knopman,William M. Meeks,Gerardo Heiss,Elizabeth G. Holliday,Peter W. Schofield,Toshiko Tanaka,David J. Stott,Jing Wang,Paul M. Ridker,Alan J. Gow,Alison Pattie,John M. Starr,Lynne J. Hocking,Nicola J. Armstrong,Stela McLachlan,Joshua M. Shulman,Luke C. Pilling,G. Eiriksdottir,Rodney J. Scott,Nicole A. Kochan,Aarno Palotie,Y-C Hsieh,Johan G. Eriksson,Alan D. Penman,Rebecca F. Gottesman,B.A. Oostra,Le Yu,Anita L. DeStefano,Alexa S. Beiser,Melissa Garcia,Jerome I. Rotter,Markus M. Noethen,Albert Hofman,P.E. Slagboom,R.G.J. Westendorp,Brendan M. Buckley,Philip A. Wolf,André G. Uitterlinden,Bruce M. Psaty,Hans-Jörgen Grabe,Stefania Bandinelli,Daniel I. Chasman,Francine Grodstein,K. Roikkonen,J-C Lambert,David J. Porteous,Jenna Price,Perminder S. Sachdev,L Ferrucci,John Attia,Igor Rudan,Caroline Hayward,Antony Wright,James F. Wilson,Sven Cichon,Lude Franke,H. Schmidt,Jun Ding,A.J.M. de Craen,Myriam Fornage,David A. Bennett,Ian J. Deary,M. A. Ikram,L. J. Launer,Annette L. Fitzpatrick,Sudha Seshadri,C M van Duijn,Thomas H. Mosley +125 more
TL;DR: A genome-wide association study of executive functioning and information processing speed in non-demented older adults from the CHARGE consortium suggests that genetic variation in the CADM2 gene is associated with individual differences in informationprocessing speed.
Journal ArticleDOI
Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
Stéphanie Debette,Stéphanie Debette,Carla A. Ibrahim Verbaas,Jan Bressler,Maaike Schuur,Albert V. Smith,Joshua C. Bis,Gail Davies,Gail Davies,Christiane Wolf,Vilmundur Gudnason,Lori B. Chibnik,Qiong Yang,Qiong Yang,Anita L. DeStefano,Anita L. DeStefano,Dominique J.-F. de Quervain,Velandai Srikanth,Velandai Srikanth,Jari Lahti,Hans J. Grabe,Hans J. Grabe,Jennifer A. Smith,Lutz Priebe,Lei Yu,Nazanin Karbalai,Caroline Hayward,James F. Wilson,Harry Campbell,K. Petrovic,Myriam Fornage,Ganesh Chauhan,Robin Yeo,Ruth Boxall,James T. Becker,Oliver Stegle,Karen A. Mather,Vincent Chouraki,Qi Sun,Qi Sun,Lynda M. Rose,Susan M. Resnick,Christopher Oldmeadow,Mirna Kirin,Alan F. Wright,Maria K. Jonsdottir,Rhoda Au,Rhoda Au,Albert J. Becker,Najaf Amin,Mike A. Nalls,Stephen Turner,Sharon L.R. Kardia,Ben A. Oostra,Gwen Windham,Laura H. Coker,Wei Zhao,David S. Knopman,Gerardo Heiss,Michael Griswold,Rebecca F. Gottesman,Veronique Vitart,Nicholas D. Hastie,Lina Zgaga,Igor Rudan,Ozren Polasek,Elizabeth G. Holliday,Peter Schofield,Seung Hoan Choi,Toshiko Tanaka,Yang An,Rodney T. Perry,Richard E. Kennedy,Michèle M. Sale,Jing Wang,Virginia G. Wadley,David C. Liewald,Paul M. Ridker,Alan J. Gow,Alison Pattie,John M. Starr,David J. Porteous,David J. Porteous,Xuan Liu,Russell Thomson,Nicola J. Armstrong,Nicola J. Armstrong,Gudny Eiriksdottir,Arezoo Assareh,Nicole A. Kochan,Elisabeth Widen,Aarno Palotie,Aarno Palotie,Yi-Chen Hsieh,Johan G. Eriksson,Christian Vogler,John C. van Swieten,Joshua M. Shulman,Alexa S. Beiser,Alexa S. Beiser,Jerome I. Rotter,Carsten Oliver Schmidt,Wolfgang Hoffmann,Markus M. Nöthen,Markus M. Nöthen,Luigi Ferrucci,John Attia,John Attia,André G. Uitterlinden,Philippe Amouyel,Jean-François Dartigues,Hélène Amieva,Katri Räikkönen,Melissa E. Garcia,Philip A. Wolf,Philip A. Wolf,Albert Hofman,W. T. Longstreth,Bruce M. Psaty,Eric Boerwinkle,Philip L. DeJager,Perminder S. Sachdev,Reinhold Schmidt,Monique M.B. Breteler,Alexander Teumer,Oscar L. Lopez,Sven Cichon,Sven Cichon,Sven Cichon,Daniel I. Chasman,Francine Grodstein,Francine Grodstein,Bertram Müller-Myhsok,Christophe Tzourio,Andreas Papassotiropoulos,David A. Bennett,M. Arfan Ikram,Ian J. Deary,Cornelia M. van Duijn,Cornelia M. van Duijn,Lenore J. Launer,Annette L. Fitzpatrick,Sudha Seshadri,Sudha Seshadri,Thomas H. Mosley +144 more
TL;DR: This largest study to date exploring the genetics of memory function in ~40,000 older individuals revealed genome-wide associations and suggested an involvement of immune and ubiquitin pathways.
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment
Cornelius A. Rietveld,Sarah E. Medland,Jaime Derringer,Jian Yang,Tõnu Esko,Nicolas W. Martin,Harm-Jan Westra,Konstantin Shakhbazov,Abdel Abdellaoui,Arpana Agrawal,Eva Albrecht,Behrooz Z. Alizadeh,Najaf Amin,John Barnard,Sebastian E. Baumeister,P.J. Benke,L.F. Bielak,Jeffrey A. Boatman,Patricia A. Boyle,Gail Davies,C. deLeeuw,Niina Eklund,Daniel S. Evans,Rudolf Ferhmann,Krista Fischer,Christian Gieger,Håkon K. Gjessing,Sara Hägg,Jennifer R. Harris,Caroline Hayward,Christina Holzapfel,Carla A. Ibrahim-Verbaas,Erik Ingelsson,Bo Jacobsson,Peter K. Joshi,A. Juqessur,Marika Kaakinen,Stavroula Kanoni,Juha Karjalainen,Ivana Kolcic,K. Kristiansson,Zoltán Kutalik,Jari Lahti,Sang Hong Lee,Peng Lin,Penelope A. Lind,Yongmei Liu,Kurt Lohman,Marisa Loitfelder,Gearoid M. McMahon,Pedro Marques-Vidal,Osorio Meirelles,Lili Milani,Ronny Myhre,Marja-Liisa Nuotio,Christopher Oldmeadow,K. Petrovic,Wouter J. Peyrot,Ozren Polasek,Lydia Quaye,Eva Reinmaa,John P. Rice,Thais S. Rizzi,H. Schmidt,Reinhold Schmidt,Albert V. Smith,Jennifer A. Smith,Toshiko Tanaka,Antonio Terracciano,M.J.H.M. van deLoos,Veronique Vitart,Henry Völzke,Jürgen Wellmann,Lei Yu,Wei Zhao,Jüri Allik,John Attia,Stefania Bandinelli,François Bastardot,Jonathan P. Beauchamp,David A. Bennett,Klaus Berger,Laura J. Bierut,Dorret I. Boomsma,Ute Bültmann,Harry Campbell,Christopher F. Chabris,Lynn Cherkas,Mina K. Chung,Francesco Cucca,Mariza deAndrade,Philip L. DeJager,J.E. deNeve,Ian J. Deary,George Dedoussis,Panagiotis Deloukas,Maria Dimitriou,G. Eiriksdottir,Martin F. Elderson,Johan G. Eriksson,David M. Evans,Jessica D. Faul,Luigi Ferrucci,Melissa E. Garcia,Henrik Grönberg,Vilmundur Guonason,Per Hall,Jade Harris,Tamara B. Harris,Nicholas D. Hastie,Andrew C. Heath,Dena G. Hernandez,W. Hoffmann,Rolf Holle,Elizabeth G. Holliday,Jouke-Jan Hottenga,William G. Iacono,Thomas Illig,Marjo-Riitta Järvelin,Mika Kähönen,Jaakko Kaprio,Robert M. Kirkpatrick,Matthew Kowgier,Antti Latvala,L. J. Launer,Debbie A Lawlor,Terho Lehtimäki,Jingmei Li,Paul Lichtenstein,Peter Lichtner,D C Liewald,P. A. F. Madden,Patrik K. E. Magnusson,Tomi E. Mäkinen,G. Masala,Matt McGue,Andres Metspalu,Andreas Mielck,Michael B. Miller,Grant W. Montgomery,Sutapa Mukherjee,Dale R. Nyholt,B.A. Oostra,C. N. A. Palmer,Aarno Palotie,B.W.J.H. Penninx,Markus Perola,Patricia A Peyser,Martin Preisig,Katri Räikkönen,Olli T. Raitakari,Anu Realo,S.M. Ring,Samuli Ripatti,F. Rivadeneira Ramirez,Igor Rudan,Aldo Rustichini,Veikko Salomaa,Antti-Pekka Sarin,David Schlessinger,Rodney J. Scott,Harold Snieder,B. St Pourcain,John M. Starr,Jae Hoon Sul,Ida Surakka,Rauli Svento,Alexander Teumer,Henning Tiemeier,F.J.A. vanRooij,D.R. vanWagoner,Erkki Vartiainen,Jorma Viikari,Peter Vollenweider,J. M. Vonk,G. Waeber,David R. Weir,H. E. Wichmann,E. Widen,Gonneke Willemsen,James F. Wilson,Alan F. Wright,Dalton Conley,George Davey-Smith,Lude Franke,Patrick J. F. Groenen,Albert Hofman,Magnus Johannesson,Sharon L.R. Kardia,Robert F. Krueger,David Laibson,Nicholas G. Martin,Michelle N. Meyer,Danielle Posthuma,A.R. Thurik,Nicholas J. Timpson,A.G. Uitterlinden,C.M. vanDuijn,Peter M. Visscher,Daniel J. Benjamin,David Cesarini,Koellinger +201 more
TL;DR: Three genetic loci are found to explain variation associated with educational achievement and provide promising candidate SNPs for follow-up work, and effect size estimates can anchor power analyses in social-science genetics.