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Bruce S. Levison
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 59
Citations - 17361
Bruce S. Levison is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Trimethylamine N-oxide & Phosphatidylcholine. The author has an hindex of 32, co-authored 59 publications receiving 13947 citations. Previous affiliations of Bruce S. Levison include University of Toledo & Cleveland Clinic.
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Journal ArticleDOI
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Zeneng Wang,Elizabeth Klipfell,Brian J. Bennett,Robert A. Koeth,Bruce S. Levison,Brandon DuGar,Ariel E. Feldstein,Earl B. Britt,Xiaoming Fu,Yoon-Mi Chung,Yuping Wu,Phil Schauer,Jonathan D. Smith,Hooman Allayee,W.H. Wilson Tang,Joseph A. DiDonato,Aldons J. Lusis,Stanley L. Hazen +17 more
TL;DR: Discovery of a relationship between gut-flora-dependent metabolism of dietary phosphatidylcholine and CVD pathogenesis provides opportunities for the development of new diagnostic tests and therapeutic approaches for atherosclerotic heart disease.
Journal ArticleDOI
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
Robert A. Koeth,Zeneng Wang,Bruce S. Levison,Jennifer A. Buffa,Elin Org,Brendan Sheehy,Earl B. Britt,Xiaoming Fu,Yuping Wu,Lin Li,Jonathan D. Smith,Joseph A. DiDonato,Jun Chen,Hongzhe Li,Gary D. Wu,James D. Lewis,Manya Warrier,J. Mark Brown,Ronald M. Krauss,W.H. Wilson Tang,Frederic D. Bushman,Aldons J. Lusis,Stanley L. Hazen +22 more
TL;DR: It is demonstrated that metabolism by intestinal microbiota of dietary l-carnitine, a trimethylamine abundant in red meat, also produces TMAO and accelerates atherosclerosis in mice, and intestinal microbiota may contribute to the well-established link between high levels of red meat consumption and CVD risk.
Journal ArticleDOI
Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk
W.H. Wilson Tang,Zeneng Wang,Bruce S. Levison,Robert A. Koeth,Earl B. Britt,Xiaoming Fu,Yuping Wu,Stanley L. Hazen +7 more
TL;DR: The production of TMAO from dietary phosphatidylcholine is dependent on metabolism by the intestinal microbiota and increased levels are associated with an increased risk of incident major adverse cardiovascular events.
Journal ArticleDOI
Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis
Zeneng Wang,Adam B. Roberts,Jennifer A. Buffa,Bruce S. Levison,Weifei Zhu,Elin Org,Xiaodong Gu,Ying Huang,Maryam Zamanian-Daryoush,Miranda K. Culley,Anthony J. DiDonato,Xiaoming Fu,Jennie E. Hazen,Daniel M Krajcik,Joseph A. DiDonato,Aldons J. Lusis,Stanley L. Hazen +16 more
TL;DR: The present studies suggest that targeting gut microbial production of TMA specifically and non-lethal microbial inhibitors in general may serve as a potential therapeutic approach for the treatment of cardiometabolic diseases.
Journal ArticleDOI
Gut Microbiota-Dependent Trimethylamine N-oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease
W.H. Wilson Tang,Zeneng Wang,David J. Kennedy,Yuping Wu,Jennifer A. Buffa,Brendan Agatisa-Boyle,Xinmin S. Li,Bruce S. Levison,Stanley L. Hazen +8 more
TL;DR: Plasma TMAO levels are both elevated in patients with CKD and portend poorer long-term survival and chronic dietary exposures that increase TmaO directly contributes to progressive renal fibrosis and dysfunction in animal models.