J
Jonathan D. Smith
Researcher at Cleveland Clinic
Publications - 240
Citations - 31377
Jonathan D. Smith is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Cholesterol & Apolipoprotein E. The author has an hindex of 76, co-authored 217 publications receiving 27866 citations. Previous affiliations of Jonathan D. Smith include Cleveland Clinic Lerner Research Institute & Wake Forest University.
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Journal ArticleDOI
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Zeneng Wang,Elizabeth Klipfell,Brian J. Bennett,Robert A. Koeth,Bruce S. Levison,Brandon DuGar,Ariel E. Feldstein,Earl B. Britt,Xiaoming Fu,Yoon-Mi Chung,Yuping Wu,Phil Schauer,Jonathan D. Smith,Hooman Allayee,W.H. Wilson Tang,Joseph A. DiDonato,Aldons J. Lusis,Stanley L. Hazen +17 more
TL;DR: Discovery of a relationship between gut-flora-dependent metabolism of dietary phosphatidylcholine and CVD pathogenesis provides opportunities for the development of new diagnostic tests and therapeutic approaches for atherosclerotic heart disease.
Journal ArticleDOI
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
Robert A. Koeth,Zeneng Wang,Bruce S. Levison,Jennifer A. Buffa,Elin Org,Brendan Sheehy,Earl B. Britt,Xiaoming Fu,Yuping Wu,Lin Li,Jonathan D. Smith,Joseph A. DiDonato,Jun Chen,Hongzhe Li,Gary D. Wu,James D. Lewis,Manya Warrier,J. Mark Brown,Ronald M. Krauss,W.H. Wilson Tang,Frederic D. Bushman,Aldons J. Lusis,Stanley L. Hazen +22 more
TL;DR: It is demonstrated that metabolism by intestinal microbiota of dietary l-carnitine, a trimethylamine abundant in red meat, also produces TMAO and accelerates atherosclerosis in mice, and intestinal microbiota may contribute to the well-established link between high levels of red meat consumption and CVD risk.
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Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
Andrew S. Plump,Jonathan D. Smith,Tony Hayek,K Aalto-Setälä,Annemarie Walsh,Judy G. Verstuyft,Edward M. Rubin,Jan L. Breslow +7 more
TL;DR: apoE-deficient mice are a promising small animal model to help understand the role of apoE in vivo and the genetic and environmental determinants of atherosclerosis.
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Origin of the West Nile Virus Responsible for an Outbreak of Encephalitis in the Northeastern United States
Robert S. Lanciotti,John T. Roehrig,Vincent Deubel,Jonathan D. Smith,Michael W. Parker,K. Steele,B. Crise,K. E. Volpe,Mary B. Crabtree,Jacqueline H. Scherret,Roy A. Hall,John S. Mackenzie,C. B. Cropp,B. Panigrahy,Eileen N. Ostlund,B. Schmitt,M. Malkinson,C. Banet,Joel S. Weissman,Nicholas Komar,Harry M. Savage,Ward B. Stone,Tim McNamara,Duane J. Gubler +23 more
TL;DR: In late summer 1999, an outbreak of human encephalitis occurred in the northeastern United States that was concurrent with extensive mortality in crows (Corvus species) as well as the deaths of several exotic birds at a zoological park in the same area.
Journal ArticleDOI
Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
Maria Febbraio,Eugene A. Podrez,Jonathan D. Smith,David P. Hajjar,Stanley L. Hazen,Henry F. Hoff,Kavita Sharma,Roy L. Silverstein +7 more
TL;DR: Results support a major role for CD36 in atherosclerotic lesion development in vivo and suggest that blockade of CD36 can be protective even in more extreme proatherogenic circumstances.