M
Manya Warrier
Researcher at University of North Carolina at Chapel Hill
Publications - 17
Citations - 4445
Manya Warrier is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: White adipose tissue & Adipose tissue. The author has an hindex of 12, co-authored 15 publications receiving 3516 citations. Previous affiliations of Manya Warrier include Cleveland Clinic & University of Toledo.
Papers
More filters
Journal ArticleDOI
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
Robert A. Koeth,Zeneng Wang,Bruce S. Levison,Jennifer A. Buffa,Elin Org,Brendan Sheehy,Earl B. Britt,Xiaoming Fu,Yuping Wu,Lin Li,Jonathan D. Smith,Joseph A. DiDonato,Jun Chen,Hongzhe Li,Gary D. Wu,James D. Lewis,Manya Warrier,J. Mark Brown,Ronald M. Krauss,W.H. Wilson Tang,Frederic D. Bushman,Aldons J. Lusis,Stanley L. Hazen +22 more
TL;DR: It is demonstrated that metabolism by intestinal microbiota of dietary l-carnitine, a trimethylamine abundant in red meat, also produces TMAO and accelerates atherosclerosis in mice, and intestinal microbiota may contribute to the well-established link between high levels of red meat consumption and CVD risk.
Journal ArticleDOI
The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance.
Manya Warrier,Diana M. Shih,Amy C. Burrows,Daniel Ferguson,Anthony D. Gromovsky,Amanda L. Brown,Stephanie M. Marshall,Allison L. McDaniel,Rebecca C. Schugar,Zeneng Wang,Jessica Sacks,Xin Rong,Thomas Q. de Aguiar Vallim,Jeff W. Chou,Pavlina T. Ivanova,David S. Myers,H. Alex Brown,Richard G. Lee,Rosanne M. Crooke,Mark J. Graham,Xiuli Liu,Paolo Parini,Peter Tontonoz,Peter Tontonoz,Aldon J. Lusis,Stanley L. Hazen,Ryan E. Temel,J. Mark Brown +27 more
TL;DR: In this article, the authors performed transcriptional profiling in mouse models of altered reverse cholesterol transport (RCT) and serendipitously identified the TMAO-generating enzyme flavin monooxygenase 3 as a powerful modifier of cholesterol metabolism and RCT.
Journal ArticleDOI
Trimethylamine N-Oxide, the Microbiome, and Heart and Kidney Disease.
Steven H. Zeisel,Manya Warrier +1 more
TL;DR: The current understanding of the properties and physiological functions of TMAO, its dietary sources, and its effects on human metabolism is reviewed.
Journal ArticleDOI
The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue
Rebecca C. Schugar,Diana M. Shih,Manya Warrier,Robert N. Helsley,Amy C. Burrows,Daniel Ferguson,Amanda L. Brown,Anthony D. Gromovsky,Markus Heine,Arunachal Chatterjee,Lin Li,Xinmin S. Li,Zeneng Wang,Belinda Willard,Yong Hong Meng,Hanjun Kim,Nam Che,Calvin Pan,Richard G. Lee,Rosanne M. Crooke,Mark J. Graham,Richard E. Morton,Carl D. Langefeld,Swapan K Das,Lawrence L. Rudel,Nizar N. Zein,Arthur J. McCullough,Srinivasan Dasarathy,W.H. Wilson Tang,Bernadette O. Erokwu,Christopher A Flask,Markku Laakso,Mete Civelek,Sathyamangla V. Naga Prasad,Joerg Heeren,Aldons J. Lusis,Stanley L. Hazen,J. Mark Brown +37 more
TL;DR: It is demonstrated that the gut microbiota-initiated trimethylamine N-oxide (TMAO)-generating pathway is linked to obesity and energy metabolism and complimentary mouse and human studies indicate a negative regulatory role for FMO3 in the beiging of white adipose tissue.
Journal ArticleDOI
Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk.
Weifei Zhu,Jennifer A. Buffa,Zeneng Wang,Manya Warrier,Rebecca C. Schugar,Diana M. Shih,Nilaksh Gupta,J. C. Gregory,Elin Org,X. Fu,Ling Li,Joseph A. DiDonato,A. J. Lusis,Jonathan Mark Brown,Jonathan Mark Brown,Stanley A Hazen,Stanley A Hazen +16 more
TL;DR: Genetic manipulation of FMO3 in mice alters systemic TMAO levels and thrombosis potential and is associated with alteration of gut microbial community structure.