R
Ruitu Lv
Researcher at Fudan University
Publications - 16
Citations - 1780
Ruitu Lv is an academic researcher from Fudan University. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 14, co-authored 16 publications receiving 1150 citations. Previous affiliations of Ruitu Lv include Fudan University Shanghai Medical College.
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Journal ArticleDOI
Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal.
Jing Wen,Ruitu Lv,Honghui Ma,Hongjie Shen,Chenxi He,Jiahua Wang,Fangfang Jiao,Hang Liu,Pengyuan Yang,Li Tan,Fei Lan,Yujiang Geno Shi,Yujiang Geno Shi,Chuan He,Chuan He,Yang Shi,Jianbo Diao +16 more
TL;DR: It is demonstrated that Zc3h13 plays a critical role in anchoring WTAP, Virilizer, and Hakai in the nucleus to facilitate m6A methylation and to regulate mESC self-renewal.
Journal ArticleDOI
Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer
Di Wu,Di Wu,Di Hu,Di Hu,Hao Chen,Hao Chen,Guo-Ming Shi,Guo-Ming Shi,Irfete S. Fetahu,Feizhen Wu,Feizhen Wu,Kimberlie Rabidou,Rui Fang,Li Tan,Shuyun Xu,Hang Liu,Christian Argueta,Lei Zhang,Fei Mao,Guoquan Yan,Jiajia Chen,Zhao-Ru Dong,Ruitu Lv,Yufei Xu,Mei Wang,Yong Ye,Shike Zhang,Danielle Duquette,Songmei Geng,Clark Yin,Christine G. Lian,George F. Murphy,Gail K. Adler,Rajesh Garg,Lydia Lynch,Pengyuan Yang,Yiming Li,Fei Lan,Jia Fan,Yang Shi,Yang Shi,Yujiang Geno Shi,Yujiang Geno Shi +42 more
TL;DR: A new model for how a pernicious environment can directly reprogram the epigenome towards an oncogenic state is presented, offering a potential strategy for cancer prevention and treatment.
Journal ArticleDOI
N 6- Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation
Honghui Ma,Honghui Ma,Honghui Ma,Xiaoyun Wang,Jia-Bin Cai,Qing Dai,Qing Dai,S. Kundhavai Natchiar,Ruitu Lv,Kai Chen,Kai Chen,Zhike Lu,Zhike Lu,Hao Chen,Yujiang Geno Shi,Yujiang Geno Shi,Fei Lan,Jia Fan,Bruno P. Klaholz,Tao Pan,Yang Shi,Yang Shi,Chuan He,Chuan He +23 more
TL;DR: A new m6A methyltransferase, ZCCHC4, is reported, which primarily methylates human 28S rRNA and also interacts with a subset of mRNAs, and was identified as a mammalian ribosome RNA (rRNA) N6-methyladenosine (m6A) writer protein that installs m 6A 4220 in 28s rRNA.
Journal ArticleDOI
BS69/ZMYND11 Reads and Connects Histone H3.3 Lysine 36 Trimethylation-Decorated Chromatin to Regulated Pre-mRNA Processing
Rui Guo,Lijuan Zheng,Juw Won Park,Ruitu Lv,Hao Chen,Fangfang Jiao,Wenqi Xu,Shi-Rong Mu,Hong Wen,Jinsong Qiu,Zhentian Wang,Pengyuan Yang,Feizhen Wu,Jingyi Hui,Xiang-Dong Fu,Xiaobing Shi,Xiaobing Shi,Yujiang Geno Shi,Yi Xing,Fei Lan,Yang Shi,Yang Shi,Yang Shi +22 more
TL;DR: This study identifies an H.3.3K36me3-specific reader and a regulator of IR and reveals that BS69 connects histone H3.
Journal ArticleDOI
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation
Shuzhen Chen,Jian Ma,Feizhen Wu,Li Jun Xiong,Honghui Ma,Wenqi Xu,Ruitu Lv,Xiaodong Li,Judit Villén,Steven P. Gygi,Xiaole Shirley Liu,Yang Shi +11 more
TL;DR: The model whereby JMJD3 activates bivalent gene transcription by demethylating H3K27me3 and promoting transcriptional elongation is supported, and new insight is provided into the mechanisms by whichJMJD3 regulates gene expression.