B
Bryan E. Snow
Researcher at Princess Margaret Cancer Centre
Publications - 43
Citations - 9855
Bryan E. Snow is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Telomere & RGS Proteins. The author has an hindex of 31, co-authored 41 publications receiving 9289 citations. Previous affiliations of Bryan E. Snow include University of Toronto & Ontario Institute for Cancer Research.
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Journal ArticleDOI
Molecular characterization of mitochondrial apoptosis-inducing factor
Santos A. Susin,Hans K. Lorenzo,Naoufal Zamzami,Isabel Marzo,Bryan E. Snow,Joan Mangion,Etienne Jacotot,Paola Costantini,Markus Loeffler,Nathanael Larochette,David R. Goodlett,Ruedi Aebersold,David P. Siderovski,Josef M. Penninger,Guido Kroemer +14 more
TL;DR: The identification and cloning of an apoptosis-inducing factor, AIF, which is sufficient to induce apoptosis of isolated nuclei is reported, indicating that AIF is a mitochondrial effector of apoptotic cell death.
Journal ArticleDOI
Regulation of PTEN transcription by p53.
Vuk Stambolic,David MacPherson,D. Sas,Yunping Lin,Bryan E. Snow,Y. Jang,Samuel Benchimol,Tak W. Mak +7 more
TL;DR: A unique role for p53 in regulation of cellular survival and an interesting connection in tumor suppressor signaling is revealed and a new element controlling constitutive expression of PTEN is identified.
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DJ-1, a novel regulator of the tumor suppressor PTEN.
Raymond H. Kim,Malte Peters,Yingju Jang,Yingju Jang,Wei Shi,Melania Pintilie,Graham C. Fletcher,Carmela DeLuca,Jennifer Liepa,Lily Zhou,Bryan E. Snow,Richard Binari,Armen S. Manoukian,Mark R. Bray,Fei-Fei Liu,Ming-Sound Tsao,Tak W. Mak,Tak W. Mak +17 more
TL;DR: DJ-1 expression was increased compared to paired nonneoplastic lung tissue, and correlated positively with relapse incidence, and is thus a key negative regulator of PTEN that may be a useful prognostic marker for cancer.
Journal Article
Overexpression of AKT2/Protein Kinase Bβ Leads to Up-Regulation of β1 Integrins, Increased Invasion, and Metastasis of Human Breast and Ovarian Cancer Cells
M. Jane Arboleda,John Lyons,Fairooz F. Kabbinavar,Mark R. Bray,Bryan E. Snow,Raul Ayala,Mordechai Danino,Beth Y. Karlan,Dennis J. Slamon +8 more
TL;DR: Overexpression of AKT2, but not AKT1 or AKT3, was sufficient to duplicate the invasive effects of phosphoinositide 3-OH kinase (PI3-K) transfected in breast cancer cells, indicating thatAKT2 mediates PI3- K-dependent effects on adhesion, motility, invasion, and metastasis in vivo.
Journal ArticleDOI
Dynamic Regulation of RGS2 Suggests a Novel Mechanism in G-Protein Signaling and Neuronal Plasticity
Tatsuya Ingi,Andrejs M. Krumins,Peter Chidiac,Stephen Chung,Bryan E. Snow,Carol A. Barnes,Anthony Lanahan,David P. Siderovski,Elliott M. Ross,Alfred G. Gilman,Paul F. Worley +10 more
TL;DR: It is demonstrated that mRNA encoding a member of the regulator of G-protein signaling (RGS) family, RGS2, is rapidly induced in neurons of the hippocampus, cortex, and striatum in response to stimuli that evoke plasticity.