M
Mark R. Bray
Researcher at University Health Network
Publications - 68
Citations - 3360
Mark R. Bray is an academic researcher from University Health Network. The author has contributed to research in topics: Cancer & Kinase. The author has an hindex of 24, co-authored 55 publications receiving 2997 citations. Previous affiliations of Mark R. Bray include Durham University & University of British Columbia.
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Journal ArticleDOI
DJ-1, a novel regulator of the tumor suppressor PTEN.
Raymond H. Kim,Malte Peters,Yingju Jang,Yingju Jang,Wei Shi,Melania Pintilie,Graham C. Fletcher,Carmela DeLuca,Jennifer Liepa,Lily Zhou,Bryan E. Snow,Richard Binari,Armen S. Manoukian,Mark R. Bray,Fei-Fei Liu,Ming-Sound Tsao,Tak W. Mak,Tak W. Mak +17 more
TL;DR: DJ-1 expression was increased compared to paired nonneoplastic lung tissue, and correlated positively with relapse incidence, and is thus a key negative regulator of PTEN that may be a useful prognostic marker for cancer.
Journal ArticleDOI
The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses
Woong-Kyung Suh,Beata U. Gajewska,Hitoshi Okada,Matthew A. Gronski,Edward M. Bertram,Wojciech Dawicki,Gordon S. Duncan,Jacob Bukczynski,Suzanne Plyte,Andrew E. H. Elia,Andrew Wakeham,Annick Itie,Stephen Chung,Joan da Costa,Sudha Arya,Tom Horan,Pauline Campbell,Kevin Gaida,Pamela S. Ohashi,Tania H. Watts,Steven Kiyoshi Yoshinaga,Mark R. Bray,Manel Jordana,Tak W. Mak +23 more
TL;DR: B7-H3 is a negative regulator that preferentially affects TH1 responses and develops experimental autoimmune encephalomyelitis several days earlier than their wild-type littermates, and accumulated higher concentrations of autoantibodies to DNA.
Journal Article
Overexpression of AKT2/Protein Kinase Bβ Leads to Up-Regulation of β1 Integrins, Increased Invasion, and Metastasis of Human Breast and Ovarian Cancer Cells
M. Jane Arboleda,John Lyons,Fairooz F. Kabbinavar,Mark R. Bray,Bryan E. Snow,Raul Ayala,Mordechai Danino,Beth Y. Karlan,Dennis J. Slamon +8 more
TL;DR: Overexpression of AKT2, but not AKT1 or AKT3, was sufficient to duplicate the invasive effects of phosphoinositide 3-OH kinase (PI3-K) transfected in breast cancer cells, indicating thatAKT2 mediates PI3- K-dependent effects on adhesion, motility, invasion, and metastasis in vivo.
Journal ArticleDOI
Targeting Mitosis in Cancer: Emerging Strategies
Carmen Dominguez-Brauer,Kelsie L. Thu,Jacqueline M. Mason,Heiko Blaser,Mark R. Bray,Tak W. Mak +5 more
TL;DR: The concept of exploiting the genomic instability of tumor cells through therapeutic inhibition of mitotic checkpoints is discussed, and it is believed this strategy has a high likelihood of success given its potential to enhance therapeutic index by targeting tumor-specific vulnerabilities.
Journal ArticleDOI
Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent.
Jacqueline M. Mason,Dan Chi-Chia Lin,Xin Wei,Yi Che,Yi Yao,Reza Kiarash,David W. Cescon,Graham C. Fletcher,Donald E. Awrey,Mark R. Bray,Guohua Pan,Tak W. Mak +11 more
TL;DR: These findings provide a rationale for the clinical evaluation of CFI-400945 in patients with solid tumors, in particular those deficient in PTEN, and allow for the significant inhibition of tumor growth at doses that are well tolerated.